Shi Liangwen, Kuang Zhixing, Tu Jiannan, Wang Taiqin, Liu Tao, Liu Jingbo, Liu Jianzhi
Department of Otorhinolaryngology, Fujian Medical University Union Hospital, Fuzhou, China.
Department of Radiotherapy, Fujian Medical University Union Hospital, Fuzhou, China.
Front Public Health. 2025 May 9;13:1583045. doi: 10.3389/fpubh.2025.1583045. eCollection 2025.
Laryngeal cancer, predominantly linked to smoking, persists as a formidable global health challenge. Acquiring a deeper understanding of laryngeal cancer attributable to smoking (LCAS) burden and trends is essential for crafting nuanced and impactful prevention and intervention strategies.
The Disability-Adjusted Life Years (DALYs), mortality, and corresponding Age-Standardized DALY rate (ASDR) and Age-Standardized Mortality Rate (ASMR) were systematically evaluated using the GBD 2021 data. Temporal trends were characterized through Joinpoint regression analysis, while the influence of socioeconomic factors on disease distribution and the associated disparities was probed through correlation analysis. Decomposition analysis was employed to identify the key factors driving changes in DALY and mortality burdens, and the Bayesian Age-Period-Cohort (BAPC) model was used to project future trends.
Over the past 30 years, the global burden of LCAS, as measured by DALYs and the number of deaths, has remained relatively stable with a modest increase of approximately 20.8 and 11.53%, respectively. However, both ASDR and ASMR have shown a decline, from 44.42 to 23.38 and from 1.61 to 0.89, respectively. Regionally, the burden is predominantly concentrated in Asia, Europe, as well as North Africa and the Middle East. In all regions, both ASDRs and ASMRs are on a downward trajectory, with the rate of decline being more pronounced as socio-economic indices (SDI) rise. Notably, Australasia, High-income Asia Pacific, and Western Europe exhibit the largest annual reductions in ASDRs and ASMRs. Population aging has been identified as the primary driver of DALYs and mortality burden in High-income Asia Pacific, while population growth plays a more significant role in other regions. In the next 15 years, both ASDR and ASMR are expected to continue their decline.
Despite progress in reducing LCAS rates over 30 years, regional disparities persist, strengthened tobacco control measures are essential to further alleviate the LCAS burden and reduce smoking-related mortality.
喉癌主要与吸烟有关，仍然是一项严峻的全球健康挑战。深入了解吸烟所致喉癌（LCAS）的负担和趋势，对于制定细致入微且有效的预防和干预策略至关重要。
使用全球疾病负担研究（GBD）2021数据，系统评估伤残调整生命年（DALYs）、死亡率以及相应的年龄标准化DALY率（ASDR）和年龄标准化死亡率（ASMR）。通过Joinpoint回归分析描述时间趋势，通过相关分析探究社会经济因素对疾病分布及相关差异的影响。采用分解分析确定导致DALY和死亡率负担变化的关键因素，并使用贝叶斯年龄-时期-队列（BAPC）模型预测未来趋势。
在过去30年中，以DALYs和死亡人数衡量的全球LCAS负担相对稳定，分别略有增加约20.8%和11.53%。然而，ASDR和ASMR均呈下降趋势，分别从44.42降至23.38，以及从1.61降至0.89。在区域层面，负担主要集中在亚洲、欧洲以及北非和中东地区。在所有地区，ASDR和ASMR均呈下降趋势，随着社会经济指数（SDI）上升，下降速度更为明显。值得注意的是，澳大拉西亚、高收入亚太地区和西欧的ASDR和ASMR年度降幅最大。人口老龄化被确定为高收入亚太地区DALYs和死亡率负担的主要驱动因素，而人口增长在其他地区发挥着更重要的作用。预计在未来15年，ASDR和ASMR将继续下降。
尽管在过去30年中降低LCAS发病率方面取得了进展，但区域差异仍然存在，加强烟草控制措施对于进一步减轻LCAS负担和降低吸烟相关死亡率至关重要。
