Qiu Jie, Zheng Qinghui, Meng Xuli
Zhejiang Chinese Medical University, Hangzhou, China.
Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Front Oncol. 2021 Feb 25;11:628359. doi: 10.3389/fonc.2021.628359. eCollection 2021.
Female breast cancer is a complex, multifactorial disease. Studies have shown that hyperglycemia is one of the most important contributing factors to increasing the risk of breast cancer that also has a major impact on the efficacy of chemotherapy. At the cellular level, hyperglycemia can promote the proliferation, invasion, and migration of breast cancer cells and can also induce anti-apoptotic responses to enhance the chemoresistance of tumors abnormal glucose metabolism. In this article, we focus on the latest progress in defining the mechanisms of chemotherapy resistance in hyperglycemic patients including the abnormal behaviors of cancer cells in the hyperglycemic microenvironment and the impact of abnormal glucose metabolism on key signaling pathways. To better understand the advantages and challenges of breast cancer treatments, we explore the causes of drug resistance in hyperglycemic patients that may help to better inform the development of effective treatments.
女性乳腺癌是一种复杂的多因素疾病。研究表明，高血糖是增加乳腺癌风险的最重要因素之一，对化疗疗效也有重大影响。在细胞水平上，高血糖可促进乳腺癌细胞的增殖、侵袭和迁移，还可诱导抗凋亡反应以增强肿瘤对化疗的耐药性及异常糖代谢。在本文中，我们重点关注在确定高血糖患者化疗耐药机制方面的最新进展，包括癌细胞在高血糖微环境中的异常行为以及异常糖代谢对关键信号通路的影响。为了更好地理解乳腺癌治疗的优势和挑战，我们探讨了高血糖患者耐药的原因，这可能有助于为有效治疗的开发提供更好的信息。
