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2
Are clinicopathological features of colorectal cancers with methylation in half of CpG island methylator phenotype panel markers different from those of CpG island methylator phenotype-high colorectal cancers?在CpG岛甲基化表型面板标记中甲基化程度达一半的结直肠癌的临床病理特征与CpG岛甲基化表型高的结直肠癌的临床病理特征是否不同？
Hum Pathol. 2016 Jan;47(1):85-94. doi: 10.1016/j.humpath.2015.09.008. Epub 2015 Sep 25.
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Epigenetic alterations in colorectal cancer: the CpG island methylator phenotype.结直肠癌中的表观遗传学改变：CpG 岛甲基化表型。
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CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer.CpG岛甲基化表型与日本转移性结直肠癌患者基于奥沙利铂和伊立替康的序贯化疗疗效及表皮生长因子受体（EGFR）相关基因突变有关。
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本文引用的文献

1
Epidemiology and Molecular-Pathologic Characteristics of CpG Island Methylator Phenotype (CIMP) in Colorectal Cancer.结直肠癌中CpG岛甲基化表型（CIMP）的流行病学及分子病理特征
Clin Colorectal Cancer. 2021 Jun;20(2):137-147.e1. doi: 10.1016/j.clcc.2020.09.007. Epub 2020 Oct 12.
2
Targeting the epigenetic regulation of antitumour immunity.靶向抗肿瘤免疫的表观遗传调控。
Nat Rev Drug Discov. 2020 Nov;19(11):776-800. doi: 10.1038/s41573-020-0077-5. Epub 2020 Sep 14.
3
Cancer registration in China and its role in cancer prevention and control.中国的癌症登记及其在癌症防控中的作用。
Lancet Oncol. 2020 Jul;21(7):e342-e349. doi: 10.1016/S1470-2045(20)30073-5.
4
Primary Tumor Location as a Prognostic and Predictive Marker in Metastatic Colorectal Cancer (mCRC).原发性肿瘤位置作为转移性结直肠癌（mCRC）的预后和预测标志物
Front Oncol. 2020 Jun 16;10:964. doi: 10.3389/fonc.2020.00964. eCollection 2020.
5
Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer.结直肠癌 CpG 岛甲基化表型在全球的流行差异。
BMC Cancer. 2019 Oct 17;19(1):964. doi: 10.1186/s12885-019-6144-9.
6
Epidrugs: targeting epigenetic marks in cancer treatment.表观遗传学药物：癌症治疗中的靶向表观遗传标记。
Epigenetics. 2019 Dec;14(12):1164-1176. doi: 10.1080/15592294.2019.1640546. Epub 2019 Jul 13.
7
Phase I clinical trial of decitabine (5-aza-2'-deoxycytidine) administered by hepatic arterial infusion in patients with unresectable liver-predominant metastases.肝动脉灌注地西他滨（5-氮杂-2'-脱氧胞苷）用于不可切除的以肝脏为主的转移瘤患者的I期临床试验。
ESMO Open. 2019 Mar 5;4(2):e000464. doi: 10.1136/esmoopen-2018-000464. eCollection 2019.
8
Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.结直肠癌的分子分类：BRAF、KRAS、微卫星不稳定性和 CIMP 状态：预后意义和对化疗的反应。
PLoS One. 2018 Sep 6;13(9):e0203051. doi: 10.1371/journal.pone.0203051. eCollection 2018.
9
DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.人类结直肠癌中 PD-1、CTLA-4、TIM-3、LAG-3、TIGIT、PD-L1 和半乳糖凝集素-9 基因启动子中的 DNA 甲基化和抑制组蛋白
Clin Epigenetics. 2018 Aug 6;10(1):104. doi: 10.1186/s13148-018-0539-3.
10
Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.奥沙利铂为基础的辅助化疗治疗 III 期结肠癌中甲基化表型的预后价值。
Clin Cancer Res. 2018 Oct 1;24(19):4745-4753. doi: 10.1158/1078-0432.CCR-18-0866. Epub 2018 Jun 19.

CpG岛甲基化表型结直肠癌治疗的进展

Advances in CpG Island Methylator Phenotype Colorectal Cancer Therapies.

作者信息

Zhang Xiaofei, Zhang Wenjun, Cao Pingan

机构信息

Department of Medical Oncology, Dalian University Affiliated Xinhua Hospital, Dalian, China.

Department of Colorectal Surgery, Dalian University Affiliated Xinhua Hospital, Dalian, China.

出版信息

Front Oncol. 2021 Feb 26;11:629390. doi: 10.3389/fonc.2021.629390. eCollection 2021.

DOI:10.3389/fonc.2021.629390
PMID:33718206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7952756/
Abstract

With the aging of the population, the incidence of colorectal cancer in China is increasing. One of the epigenetic alterations: CpG island methylator phenotype (CIMP) plays an important role in the incidence of colorectal cancer. Recent studies have shown that CIMP is closely related to some specific clinicopathological phenotypes and multiple molecular phenotypes in colorectal cancer. In this paper, the newest progress of CIMP colorectal cancer in chemotherapeutic drugs, targeted agents and small molecular methylation inhibitors are going to be introduced. We hope to provide potential clinical treatment strategies for personalized and precise treatment of colorectal cancer patients.

摘要

随着人口老龄化，中国结直肠癌的发病率正在上升。表观遗传改变之一：CpG岛甲基化表型（CIMP）在结直肠癌的发病中起重要作用。最近的研究表明，CIMP与结直肠癌的一些特定临床病理表型和多种分子表型密切相关。本文将介绍CIMP结直肠癌在化疗药物、靶向药物和小分子甲基化抑制剂方面的最新进展。我们希望为结直肠癌患者的个性化精准治疗提供潜在的临床治疗策略。