Wang Lei, Qin Xiaowei, Liang Jianmin, Ge Pengfei
Department of Neurosurgery, First Hospital of Jilin University, Jilin University, Changchun, China.
Department of Pediatric Neurology, First Hospital of Jilin University, Jilin University, Changchun, China.
Front Oncol. 2021 Feb 26;11:635774. doi: 10.3389/fonc.2021.635774. eCollection 2021.
Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of pyroptosis. Emerging evidence has revealed a complicated relationship between pyroptosis and cancer. On the one hand, as inflammatory cell death, pyroptosis provides a comfortable environment for tumor proliferation. On the other hand, excessive activation of pyroptosis can inhibit the development of tumor cells. In this review, we first summarized the latest progress about the molecular mechanism of pyroptosis. Then, members from gasdermin family, the central molecules of pyroptosis which formed pores on the cell membrane, were highlighted. In the second part of this review, we summarized drugs that induced pyroptosis in different tumors and their concrete mechanisms based on recent literature reports. In the final section, we discussed several hotspots in pyroptosis and cancer therapy, which will point out the direction of sequent research. In brief, inducing pyroptosis in cancer cells is a promising strategy for cancer therapy.
细胞焦亡是一种溶解性促炎性程序性细胞死亡，已在多种炎症性疾病模型中得到广泛研究。由裂解的gasdermin家族成员诱导的膜穿孔和细胞肿胀是细胞焦亡的主要特征。新出现的证据揭示了细胞焦亡与癌症之间复杂的关系。一方面，作为炎性细胞死亡，细胞焦亡为肿瘤增殖提供了适宜的环境。另一方面，细胞焦亡的过度激活可抑制肿瘤细胞的发展。在本综述中，我们首先总结了细胞焦亡分子机制的最新进展。然后，重点介绍了gasdermin家族成员，它们是细胞焦亡的核心分子，可在细胞膜上形成孔道。在本综述的第二部分，我们根据最近的文献报道，总结了在不同肿瘤中诱导细胞焦亡的药物及其具体机制。在最后一部分，我们讨论了细胞焦亡和癌症治疗中的几个热点问题，这将为后续研究指明方向。简而言之，诱导癌细胞发生细胞焦亡是一种很有前景的癌症治疗策略。
