Lu Liqing, Zhang Ye, Tan Xuemei, Merkher Yulia, Leonov Sergey, Zhu Li, Deng Yalan, Zhang Huajun, Zhu Dandan, Tan Yuying, Fu Ying, Liu Ting, Chen Yongheng
Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
Department of Oncology, NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratory for Anticancer Drugs, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Cell Death Discov. 2022 Jul 27;8(1):338. doi: 10.1038/s41420-022-01101-6.
Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying pyroptosis activation and the signalling pathways regulated by pyroptosis remain unclear. In this review, we first briefly introduce the definition, morphological characteristics, and activation pathways of pyroptosis and the effect of pyroptosis on anticancer immunity. Then we review recent progress concerning the complex role of pyroptosis in various tumours. Importantly, we summarise various FDA-approved chemotherapy drugs or natural compounds that exerted antitumor properties by inducing pyroptosis of cancer cells. Moreover, we also focus on the current application of nanotechnology-induced pyroptosis in tumour therapy. In addition, some unsolved problems and potential future research directions are also raised.
细胞焦亡是一种炎症性程序性细胞死亡，由半胱天冬酶切割gasdermin家族蛋白引发。基于越来越多的证据，细胞焦亡与肿瘤发展密切相关，但细胞焦亡激活的分子机制以及受细胞焦亡调节的信号通路仍不清楚。在本综述中，我们首先简要介绍细胞焦亡的定义、形态特征、激活途径以及细胞焦亡对抗癌免疫的影响。然后我们回顾了细胞焦亡在各种肿瘤中的复杂作用的最新进展。重要的是，我们总结了各种FDA批准的化疗药物或天然化合物，它们通过诱导癌细胞焦亡发挥抗肿瘤特性。此外，我们还关注纳米技术诱导的细胞焦亡在肿瘤治疗中的当前应用。此外，还提出了一些未解决的问题和潜在的未来研究方向。
