Pichler Sekulic Simona, Sekulic Miroslav
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
Front Cardiovasc Med. 2021 Feb 25;8:615707. doi: 10.3389/fcvm.2021.615707. eCollection 2021.
Cardiac valve inflammation is seen in the setting of autoimmune or infectious processes, and rarely is valvulitis characterized by granulomatous inflammation. We present two patients who underwent surgical repair of prolapsing/regurgitating mitral valves. Excised valve tissue in both cases revealed commonly encountered nodular fibrosis and calcification, however each also revealed an isolated focus of non-necrotizing granulomatous inflammation. Typical implicating etiologies for non-necrotizing granulomatous inflammation were not present for either patient based on clinical history, or radiologic and laboratory data. In a review of 1048 cardiac valves excised at our institution, the finding of non-necrotizing granulomatous inflammation was seen in only the two described cases (prevalence of 0.19%). The description of non-necrotizing granulomatous inflammation within cardiac valves is limited in the literature, and the significance of the detailed isolated and incidental finding is unclear and requiring further investigation.
心脏瓣膜炎症见于自身免疫或感染性疾病背景下，而瓣膜炎很少以肉芽肿性炎症为特征。我们报告了两名接受二尖瓣脱垂/反流手术修复的患者。两例切除的瓣膜组织均显示常见的结节性纤维化和钙化，但每例也都发现了一个孤立的非坏死性肉芽肿性炎症灶。根据临床病史、影像学和实验室数据，两名患者均不存在典型的非坏死性肉芽肿性炎症相关病因。在对我院切除的1048个心脏瓣膜进行回顾时，仅在上述两例中发现了非坏死性肉芽肿性炎症（患病率为0.19%）。文献中对心脏瓣膜内非坏死性肉芽肿性炎症的描述有限，这种详细的孤立性偶然发现的意义尚不清楚，需要进一步研究。
