Molecular Determinants Core, Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, USA.
Program in Individualized Medicine, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
J Vet Pharmacol Ther. 2021 Nov;44(6):855-869. doi: 10.1111/jvp.12961. Epub 2021 Mar 14.
Metabolomics is the large-scale study of low-molecular-weight substances in a biological system in a given physiological state at a given time point. Metabolomics can be applied to identify predictors of inter-individual variability in drug response, provide clinicians with data useful for decision-making processes in drug selection, and inform about the pharmacokinetics and pharmacodynamics of a drug. It is, therefore, an exceptional approach for gaining new understanding effects in the field of comparative veterinary pharmacology. However, the incorporation of metabolomics into veterinary pharmacology and toxicology is not yet widespread, and this is probably, at least in part, a result of its highly multidisciplinary nature. This article reviews the potential applications of metabolomics in veterinary pharmacology and therapeutics. It integrates key concepts for designing metabolomics studies and analyzing and interpreting metabolomics data, providing solid foundations for applying metabolomics to the study of drugs in all veterinary species.
代谢组学是在给定的生理状态下，在给定的时间点，对生物系统中低分子量物质的大规模研究。代谢组学可用于鉴定药物反应个体间变异性的预测因子，为临床医生提供药物选择决策过程中有用的数据，并提供有关药物药代动力学和药效学的信息。因此，它是在比较兽医药理学领域获得新的作用机制理解的一种特殊方法。然而，代谢组学在兽医药理学和毒理学中的应用尚未广泛普及，这至少部分是由于其高度的多学科性质。本文综述了代谢组学在兽医药理学和治疗学中的潜在应用。它整合了设计代谢组学研究以及分析和解释代谢组学数据的关键概念，为将代谢组学应用于所有兽医物种的药物研究提供了坚实的基础。
