Ren Yixing, Huang Ruoyu, Wang Cunyang, Ma Yajie, Li Xiaoming
Department of Orthopedics, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P.R.China.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Mar 15;35(3):271-277. doi: 10.7507/1002-1892.202009073.
With the in-depth research on bone repair process, and the progress in bone repair materials preparation and characterization, a variety of artificial bone substitutes have been fully developed in the treatment of bone related diseases such as bone defects. However, the current various natural or synthetic biomaterials are still unable to achieve the structure and properties of natural bone. Carbon nanotubes (CNTs) have provided a new direction for the development of new materials in the field of bone repair due to their excellent structural stability, mechanical properties, and functional group modifiability. Moreover, CNTs and their composites have broad prospects in the design of bone repair materials and as drug delivery carriers. This paper describes the advantages of CNTs related to bone tissue regeneration from the aspects of morphology, chemistry, mechanics, electromagnetism, and biosafety, as well as the application of CNTs in drug delivery carriers and reinforcement components of scaffold materials. In addition, the potential problems and prospects of CNTs in bone regenerative medicine are discussed.
随着对骨修复过程的深入研究,以及骨修复材料制备与表征方面的进展,在治疗诸如骨缺损等骨相关疾病时,已充分开发出多种人工骨替代物。然而,当前各种天然或合成生物材料仍无法实现天然骨的结构与性能。碳纳米管(CNTs)因其优异的结构稳定性、力学性能和官能团可修饰性,为骨修复领域的新材料开发提供了新方向。此外,碳纳米管及其复合材料在骨修复材料设计和作为药物递送载体方面具有广阔前景。本文从形态学、化学、力学、电磁学和生物安全性等方面阐述了碳纳米管与骨组织再生相关的优势,以及碳纳米管在药物递送载体和支架材料增强组分中的应用。此外,还讨论了碳纳米管在骨再生医学中存在的潜在问题和前景。