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临床实践:在醒后卒中的活动期癌症患者中进行静脉溶栓治疗。

Clinical practice: intravenous thrombolysis in a patient with active cancer who experienced wake-up stroke.

机构信息

Department of Neurology, Hainan Hospital of Chinese PLA General Hospital, Sanya, China.

Department of Neurology, Cadre Sanatorium of Hainan (Geriatric Hospital of Hainan), Haikou, China.

出版信息

J Int Med Res. 2021 Mar;49(3):3000605211000155. doi: 10.1177/03000605211000155.

DOI:10.1177/03000605211000155
PMID:33719669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7960903/
Abstract

After reviewing the diagnosis and treatment process of a patient with active cancer who experienced wake-up stroke, we have summarized the clinical manifestations, laboratory examination results, imaging features, pathological results, and treatment in this report. Patients with active cancer who experience wake-up stroke often have mild neurological deficits at the time of onset. For the patient in this study, laboratory test results were mainly characterized by abnormal coagulation function and elevated tumor markers. The brain magnetic resonance imaging (MRI) images were characterized by involvement of both the arterial and venous systems. Thrombolytic therapy during the window period can improve the symptoms of neurological deficits. Overall, anticoagulation therapy was safe and effective in our patient.

摘要

在回顾了一位患有活动性癌症并经历了觉醒性中风的患者的诊断和治疗过程后,我们总结了本报告中的临床表现、实验室检查结果、影像学特征、病理结果和治疗方法。患有活动性癌症并经历觉醒性中风的患者在发病时通常会出现轻度神经功能缺损。对于本研究中的患者,实验室检查结果主要表现为凝血功能异常和肿瘤标志物升高。脑部磁共振成像(MRI)图像的特征是同时累及动脉和静脉系统。在窗口期进行溶栓治疗可以改善神经功能缺损的症状。总的来说,抗凝治疗对我们的患者是安全有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/3e4f9215d991/10.1177_03000605211000155-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/0bfeee73da5b/10.1177_03000605211000155-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/2dccbcb55298/10.1177_03000605211000155-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/548e56ad1626/10.1177_03000605211000155-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/a394d85e9753/10.1177_03000605211000155-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/d44c369e3c4d/10.1177_03000605211000155-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/bf542e6394ee/10.1177_03000605211000155-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/3e4f9215d991/10.1177_03000605211000155-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/0bfeee73da5b/10.1177_03000605211000155-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/2dccbcb55298/10.1177_03000605211000155-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/548e56ad1626/10.1177_03000605211000155-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/a394d85e9753/10.1177_03000605211000155-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/d44c369e3c4d/10.1177_03000605211000155-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/bf542e6394ee/10.1177_03000605211000155-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb5b/7960903/3e4f9215d991/10.1177_03000605211000155-fig7.jpg

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本文引用的文献

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Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke.肺癌相关急性缺血性脑卒中的临床特征及危险因素。
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Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer.急性缺血性脑卒中合并活动性癌症的静脉溶栓治疗。
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Clinical and Neuroimaging Features of Acute Ischemic Stroke in Cancer Patients.癌症患者急性缺血性卒中的临床及神经影像学特征
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10
A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP).一项多中心、随机、双盲、安慰剂对照试验,旨在测试基于磁共振成像的溶栓治疗在醒后卒中(WAKE-UP)中的疗效和安全性。
Int J Stroke. 2014 Aug;9(6):829-36. doi: 10.1111/ijs.12011. Epub 2013 Mar 12.