Department of Radiotherapy and Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
Laryngoscope. 2021 Sep;131(9):2023-2029. doi: 10.1002/lary.29491. Epub 2021 Mar 15.
OBJECTIVE/HYPOTHESIS: To estimate the prevalence of baseline clinically significant distress (distress score ≥ 4) in head and neck cancer patients planned and treated with radical intent radiotherapy using the National Comprehensive Cancer Network Distress Thermometer (DT) and assess factors predictive of distress.
Cross-sectional study.
This was a cross-sectional study evaluating distress in 600 head and neck cancer patients undergoing radiation therapy. The DT was used to screen patients for distress at baseline before radiotherapy.
The median distress score of the entire cohort was 4 interquartile range (IQR) (IQR: 3-5), and 340 patients (56.7%) had clinically significant distress. On univariate analysis, the causal factors predictive of distress were low socioeconomic status (P = .04), presence of proliferative growth at presentation (P = .008), site of the tumor (oral cavity, P = .02), comorbidity (P = .04), and presence of Ryle's tube or tracheostomy tube at baseline (P = .01). Low socioeconomic status was significant (P = .04) on multivariate analysis for high levels of distress.
Among head and neck cancer patients, 56% of patients had clinically significant baseline distress, and patients with low socioeconomic status had high distress. There is a need for interventions to mitigate distress.
4 Laryngoscope, 131:2023-2029, 2021.
目的/假设：使用美国国家综合癌症网络痛苦温度计（DT）评估计划和接受根治性放疗的头颈部癌症患者基线时临床显著痛苦（痛苦评分≥4）的患病率，并评估预测痛苦的因素。
横断面研究。
这是一项横断面研究，评估了 600 例接受放射治疗的头颈部癌症患者的痛苦。DT 在放射治疗前用于筛查基线时的患者是否存在痛苦。
整个队列的中位痛苦评分四分位距（IQR）为 4（IQR：3-5），340 例（56.7%）患者存在临床显著痛苦。单因素分析表明，痛苦的预测因素包括低社会经济地位（P =.04）、存在增殖性生长（P =.008）、肿瘤部位（口腔，P =.02）、合并症（P =.04）和基线时存在 Ryle 管或气管造口管（P =.01）。多因素分析显示，低社会经济地位对高水平的痛苦有显著影响（P =.04）。
在头颈部癌症患者中，56%的患者基线时存在临床显著痛苦，社会经济地位低的患者痛苦程度较高。需要采取干预措施来减轻痛苦。
4 Laryngoscope, 131:2023-2029, 2021.
