Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, U.S.A.
Anticancer Res. 2023 May;43(5):2227-2233. doi: 10.21873/anticanres.16386.
BACKGROUND/AIM: Radiotherapy for head-and-neck cancer is often associated with significant toxicities, which may cause emotional distress. We evaluated prevalence and risk factors for pre-treatment emotional problems in patients irradiated for head-and-neck cancer.
Twelve characteristics were retrospectively investigated in 213 patients for associations with emotional problems (worry, fear, sadness, depression, nervousness, loss of interest). After Bonferroni adjustment, p-values <0.0042 were regarded significant.
At least one emotional problem was reported by 131 patients (61.5%). Specific prevalence for emotional problems ranged between 10% and 44%. Physical complaints showed significant associations with all six emotional problems (p<0.0001) and female sex with sadness (p=0.0013). Trends were found for associations between female sex and fear (p=0.0097), history of another tumor and sadness (p=0.043), worse performance status and nervousness (p=0.012), and cancer site (oropharynx/oral cavity) and nervousness (p=0.063).
More than 60% of patients reported emotional distress prior to radiotherapy for head-and-neck cancer. Patients with risk factors likely require near-term psycho-oncological assistance.
背景/目的：头颈部癌症的放射治疗常伴有显著的毒性，这可能导致情绪困扰。我们评估了头颈部癌症放疗患者治疗前情绪问题的发生率和危险因素。
对 213 例患者的 12 个特征进行回顾性分析，以评估与情绪问题（担忧、恐惧、悲伤、抑郁、紧张、兴趣丧失）的相关性。经 Bonferroni 调整后，p 值<0.0042 被认为具有统计学意义。
131 例患者（61.5%）报告存在至少一种情绪问题。特定情绪问题的患病率在 10%至 44%之间。身体投诉与所有六种情绪问题均有显著相关性（p<0.0001），女性与悲伤（p=0.0013）相关。女性与恐惧（p=0.0097）、另一肿瘤史与悲伤（p=0.043）、较差的表现状态与紧张（p=0.012）、癌症部位（口咽/口腔）与紧张（p=0.063）之间存在相关性的趋势。
超过 60%的头颈部癌症放疗患者报告存在情绪困扰。具有危险因素的患者可能需要近期的心理肿瘤学援助。
