Department of General Courses, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Orthopedics, Isfahan University of Medical Sciences, Isfahan, Iran.
Phytother Res. 2021 Aug;35(8):4127-4135. doi: 10.1002/ptr.7075. Epub 2021 Mar 15.
We aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to examine the effect of cumin supplementation on markers of glycemic control in adults. A comprehensive literature search was conducted up from inception to November 2020 on PubMed, Scopus, Web of Sciences, and Cochrane electronic databases. Studies that compared the effect of cumin with placebo on fasting blood sugar (FBS), serum insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index in adults were considered eligible. Weighted mean difference (WMD) (with 95% confidence intervals) for endpoints were calculated using the random-effects model. Finally, a total of eight RCT studies involving 552 participants were included in the review. The results of the meta-analysis suggest that cumin supplementation did not significantly alter serum FBS (WMD: -17.77 mg/dl; 95% CI: -36.42 to 0.87, p = .06), insulin (WMD: -0.49 Hedges' g; 95% CI: -1.19 to 0.21, p =.16) levels and HOMA-IR (WMD: -0.06; 95% CI: -0.21 to 0.10, p = 0.48) index. These results do not support the use of cumin supplementation for improving glycemic markers in adults. However, further high-quality trials are still needed to confirm these results.
我们旨在进行系统评价和荟萃分析随机对照试验（RCT），以研究孜然补充剂对成年人血糖控制标志物的影响。从研究开始到 2020 年 11 月，我们在 PubMed、Scopus、Web of Sciences 和 Cochrane 电子数据库上进行了全面的文献搜索。符合条件的研究是将孜然与安慰剂对成年人空腹血糖（FBS）、血清胰岛素和稳态模型评估估计的胰岛素抵抗（HOMA-IR）指数的影响进行比较。使用随机效应模型计算终点的加权均数差（WMD）（95%置信区间）。最后，共有 8 项 RCT 研究纳入 552 名参与者。荟萃分析的结果表明，孜然补充剂并未显著改变血清 FBS（WMD：-17.77mg/dl；95%CI：-36.42 至 0.87，p=0.06）、胰岛素（WMD：-0.49 Hedge's g；95%CI：-1.19 至 0.21，p=0.16）水平和 HOMA-IR（WMD：-0.06；95%CI：-0.21 至 0.10，p=0.48）指数。这些结果不支持使用孜然补充剂来改善成年人的血糖标志物。然而，仍需要进一步的高质量试验来证实这些结果。
