School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2021 Sep;35(9):5053-5067. doi: 10.1002/ptr.7135. Epub 2021 Apr 24.
The aim of this study was to perform a systematic review and meta-analysis of randomized clinical trials (RCTs) to examine the effect of grapes/grape products supplementation on glycemic indices in adults. Our systematic search to find relevant RCTs was performed up to February 2020 using PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar. Based on the heterogeneity between included studies, a random effects or a fixed model was applied in the meta-analysis, and results were expressed as weighted mean differences (WMD) with 95% confidence intervals (CI). Twenty-nine clinical trials (1,297 participants) fulfilled the eligibility criteria of the present meta-analysis. Overall, the grapes/grape products supplementation significantly reduced homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -0.54, 95% CI: -0.91, -0.17, p = . 004) but did not affect fasting insulin levels (WMD: -0.90 μIU/ml, 95% CI: -1.04, 2.84, p = .362) and hemoglobin A1C (Hb1Ac) percentage (WMD: 0.00%, 95% CI: -0.10, 0.11, p = . 916) in the main analyses. In addition, changes to fasting blood glucose (FBG) levels were in favor of the control group (WMD: 1.19 mg/dl, 95% CI: 0.05, 2.34, p = .041). We found that giving grapes/grape products to adults might have beneficial effects on the HOMA-IR. Further, large-scale RCTs with longer duration are required to confirm these results.
本研究旨在进行系统回顾和荟萃分析，以评估葡萄/葡萄制品补充对成年人血糖指数的影响。我们系统地检索了截至 2020 年 2 月的相关随机对照试验（RCT），使用了 PubMed、Scopus、ISI Web of Science、Cochrane 图书馆和 Google Scholar。基于纳入研究之间的异质性，在荟萃分析中应用了随机效应或固定效应模型，结果表示为加权均数差值（WMD）及其 95%置信区间（CI）。29 项临床试验（1297 名参与者）符合本荟萃分析的纳入标准。总体而言，葡萄/葡萄制品补充显著降低了稳态模型评估的胰岛素抵抗（HOMA-IR）（WMD：-0.54，95%CI：-0.91，-0.17，p=0.004），但对空腹胰岛素水平（WMD：-0.90 μIU/ml，95%CI：-1.04，2.84，p=0.362）和糖化血红蛋白（Hb1Ac）百分比（WMD：0.00%，95%CI：-0.10，0.11，p=0.916）无影响。此外，空腹血糖（FBG）水平的变化对对照组有利（WMD：1.19 mg/dl，95%CI：0.05，2.34，p=0.041）。我们发现，给予成年人葡萄/葡萄制品可能对 HOMA-IR 有有益的影响。此外，需要进行更大规模、持续时间更长的 RCT 来证实这些结果。
