Siracká E, Révész L, Kovác R, Siracký J
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Int J Cancer. 1988 Jun 15;41(6):819-22. doi: 10.1002/ijc.2910410607.
The vascular density (VD) in stage-III tumors of the uterine cervix was determined by morphometric analysis of histologic, Masson-trichrome stained sections prepared from biopsies. In a retrospective study, VD was found to be related to results of radiotherapy, larger VD being associated with prolonged survival, in agreement with similar observations made earlier with stage-IB and -IIA tumors of the cervix. In a complementary study the variation of VD within tumors was investigated in relation to the variation between tumors using surgically removed cervical carcinomas in stage IB. Statistically significant F-ratios were calculated, suggesting a more or less individual pattern of vascularization of the tumors despite a considerable intra-tumoral heterogeneity of the vasculature. It is concluded that VD may reflect oxygenation of neoplastic tissue, and may have a predictive value in regard to the response of tumors to irradiation.
通过对活检组织制备的苏木精-伊红染色切片进行形态计量分析，确定子宫颈III期肿瘤的血管密度（VD）。在一项回顾性研究中，发现VD与放疗结果相关，较大的VD与生存期延长相关，这与早期对子宫颈IB期和IIA期肿瘤的类似观察结果一致。在一项补充研究中，使用IB期手术切除的子宫颈癌，研究了肿瘤内VD的变化与肿瘤间变化的关系。计算出具有统计学意义的F值，表明尽管肿瘤内血管存在相当大的异质性，但肿瘤的血管生成模式或多或少具有个体差异。得出的结论是，VD可能反映肿瘤组织的氧合情况，并且对肿瘤对放疗的反应可能具有预测价值。
