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基于坚韧多功能粒子的双网络水凝胶的 3D 打印方法。

3D Printing Method for Tough Multifunctional Particle-Based Double-Network Hydrogels.

机构信息

State Key Laboratory of Fluid Power & Mechatronic System, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Center for X-Mechanics, Department of Engineering Mechanics, Zhejiang University, Hangzhou 310027, China.

出版信息

ACS Appl Mater Interfaces. 2021 Mar 24;13(11):13714-13723. doi: 10.1021/acsami.1c01413. Epub 2021 Mar 15.

Abstract

3D printing of hydrogels finds widespread applications in biomedicine and engineering. Artificial cartilages and heart valves, tissue regeneration and soft robots, require high mechanical performance of complex structures. Although many tough hydrogels have been developed, complicated synthesis processes hinder their fabrication in 3D printing. Here, a strategy is proposed to formulate hydrogel inks, which can be printed into various strong and tough particle-based double-network (P-DN) hydrogels of arbitrary shapes without any rheological modifiers. These hydrogel inks consist of microgels and a hydrogel precursor. The microgels are individual highly cross-linked networks. They are prepared by swelling dried microparticles in the hydrogel precursor that consists of monomers, initiators, and cross-linkers. Microgels regulate the rheological properties of the hydrogel ink and enable the direct printing. After printing and curing, the precursor forms a sparsely cross-linked network that integrates the microgels, leading to a P-DN hydrogel. The proposed hydrogel inks allow 3D printing of multifunctional hydrogel structures with high mechanical performance and strong adhesion to diverse materials. This strategy will open new avenues to fabricate multifunctional devices in tissue engineering and soft robotics.

摘要

3D 打印水凝胶在生物医学和工程领域得到了广泛的应用。人工软骨和心脏瓣膜、组织再生和软机器人需要具有复杂结构的高机械性能。尽管已经开发出许多坚韧的水凝胶,但复杂的合成工艺阻碍了它们在 3D 打印中的制造。在这里,提出了一种策略来配制水凝胶墨水,可以将其打印成各种形状的强韧的基于颗粒的双网络(P-DN)水凝胶,而无需任何流变改性剂。这些水凝胶墨水由微凝胶和水凝胶前体组成。微凝胶是单独的高度交联网络。它们是通过在水凝胶前体中溶胀干燥的微颗粒制备的,水凝胶前体由单体、引发剂和交联剂组成。微凝胶调节水凝胶墨水的流变性能,并能够直接进行打印。打印和固化后,前体形成稀疏交联的网络,将微凝胶集成在一起,形成 P-DN 水凝胶。所提出的水凝胶墨水允许打印具有高机械性能和对各种材料强附着力的多功能水凝胶结构。该策略将为组织工程和软机器人领域制造多功能设备开辟新途径。

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