Fatiregun Omolara A, Oluokun Temiloluwa, Lasebikan Nwamaka N, Nwachukwu Emmanuella, Ibraheem Abiola A, Olopade Olufunmilayo
Department of Radiology, Oncology Unit, Lagos State University College of Medicine, Lagos, Nigeria.
University of Liverpool School of Medicine, Liverpool, United Kingdom.
JCO Glob Oncol. 2021 Mar;7:384-390. doi: 10.1200/GO.20.00541.
Breast cancer is the most common malignancy in women worldwide. In Nigeria, it accounts for 22.7% of all new cancer cases among women. Evidence-based medicine (EBM) entails using the results from healthcare research to enhance the clinical decision-making process and develop evidence-based treatment guidelines. Level 1 and 2 studies, such as randomized controlled trials, meta-analyses, and systematic reviews of randomized controlled trials, yield more robust types of evidence. This study reviewed the levels of evidence of breast cancer publications in Nigeria.
We conducted an electronic literature search of all studies published on breast cancer in Nigeria from January 1961 to August 2019. We reviewed all the articles found under the search term "Breast Cancer in Nigeria" on medical databases.
Our search identified 2,242 publications. One thousand two hundred fifty duplicates were removed, and 520 were excluded. A total of 472 articles were considered eligible for this review. Most of these articles were case series or reports (30.7%), qualitative studies (15.7%), followed by cross-sectional studies (13.3%), laboratory studies (12.9%), case-control studies (6.1%), case reports (7%), and cohort (5.7%).
Breast cancer research in Nigeria is yet to produce much evidence of the types considered to best support EBM. The scarcity of data hampers the implementation of EBM in Nigeria. Currently, most treatment guidelines are adapted from those developed in other countries, despite genetic differences among populations and different environmental influencing factors.
乳腺癌是全球女性中最常见的恶性肿瘤。在尼日利亚，它占女性所有新发癌症病例的22.7%。循证医学（EBM）需要利用医疗保健研究的结果来加强临床决策过程并制定循证治疗指南。一级和二级研究，如随机对照试验、荟萃分析以及随机对照试验的系统评价，能产生更强有力的证据类型。本研究回顾了尼日利亚乳腺癌出版物的证据水平。
我们对1961年1月至2019年8月在尼日利亚发表的所有关于乳腺癌的研究进行了电子文献检索。我们在医学数据库中查看了在搜索词“尼日利亚的乳腺癌”下找到的所有文章。
我们的检索共识别出2242篇出版物。去除了1250篇重复文章，并排除了520篇。共有472篇文章被认为符合本综述的要求。这些文章大多是病例系列或报告（30.7%）、定性研究（15.7%），其次是横断面研究（13.3%）、实验室研究（12.9%）、病例对照研究（6.1%）、病例报告（7%）和队列研究（5.7%）。
尼日利亚的乳腺癌研究尚未产生许多被认为最能支持循证医学的证据类型。数据的匮乏阻碍了循证医学在尼日利亚的实施。目前，尽管人群之间存在基因差异以及不同的环境影响因素，但大多数治疗指南都是借鉴其他国家制定的指南。
