Department of Gastroenterology, Dokkyo Medical University School of Medicine, Mibu, Japan.
Department of Nutritional Science, Faculty of Human Life Science, Shokei University, Kumamoto, Japan.
Biomed Mater Eng. 2021;32(2):63-71. doi: 10.3233/BME-201163.
Endoscopic transpapillary stenting is commonly performed in patients with obstructive jaundice caused by a biliary stricture. Although the plastic stent (PS) is widely used for biliary drainage because of the low-cost and easy procedure, patency is short after placement in the bile duct because of the small diameter. Dysfunction of PS is primarily caused by biliary sludge that forms as a result of bacterial adhesion and subsequent biofilm formation on the inner surface of the stent. It is well known that silver ions have excellent antibacterial activity against a wide range of microorganisms.
This review provides an overview and perspective of the significance of silver-coated biliary stents.
We collected literature regarding silver-coated biliary stents, reviewed the current research/development status and discussed their possible usefulness.
To date, several in vivo/vitro studies evaluated the patency of silver-blended or silver-coated biliary stents. These studies suggested that the silver coating on a PS was likely to prolong the patency period.
The development of biliary stents using silver is expected to prolong stent patency and prevent frequent stent replacement.
内镜经乳头胆管支架置入术常用于治疗胆管狭窄引起的阻塞性黄疸。由于塑料支架（PS）成本低、操作简单，因此被广泛应用于胆道引流，但由于其直径较小，置入胆管后的通畅时间较短。PS 功能障碍主要是由于胆汁淤积所致，这是由于细菌黏附在内支架内表面后形成生物膜。众所周知，银离子对多种微生物具有优异的抗菌活性。
本文综述了镀银胆道支架的重要性和研究进展。
我们收集了有关镀银胆道支架的文献，回顾了当前的研究/开发状况，并讨论了其可能的用途。
迄今为止，已有几项体内/体外研究评估了银混合或镀银胆道支架的通畅性。这些研究表明，PS 上的银涂层可能会延长通畅期。
使用银制造胆道支架有望延长支架通畅时间，减少频繁更换支架。
