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用于活性材料和表面改性的胆道支架：最新进展与未来展望。

Biliary stents for active materials and surface modification: Recent advances and future perspectives.

作者信息

Li Yuechuan, Yuan Kunshan, Deng Chengchen, Tang Hui, Wang Jinxuan, Dai Xiaozhen, Zhang Bing, Sun Ziru, Ren Guiying, Zhang Haijun, Wang Guixue

机构信息

Key Laboratory for Biorheological Science and Technology of Ministry of Education, National Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, China.

National United Engineering Laboratory for Biomedical Material Modification, Dezhou, 251100, China.

出版信息

Bioact Mater. 2024 Sep 13;42:587-612. doi: 10.1016/j.bioactmat.2024.08.031. eCollection 2024 Dec.

DOI:10.1016/j.bioactmat.2024.08.031
PMID:39314863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11417150/
Abstract

Demand for biliary stents has expanded with the increasing incidence of biliary disease. The implantation of plastic or self-expandable metal stents can be an effective treatment for biliary strictures. However, these stents are nondegradable and prone to restenosis. Surgical removal or replacement of the nondegradable stents is necessary in cases of disease resolution or restenosis. To overcome these shortcomings, improvements were made to the materials and surfaces used for the stents. First, this paper reviews the advantages and limitations of nondegradable stents. Second, emphasis is placed on biodegradable polymer and biodegradable metal stents, along with functional coatings. This also encompasses tissue engineering & 3D-printed stents were highlighted. Finally, the future perspectives of biliary stents, including pro-epithelialization coatings, multifunctional coated stents, biodegradable shape memory stents, and 4D bioprinting, were discussed.

摘要

随着胆道疾病发病率的上升，对胆道支架的需求不断增加。植入塑料或自膨胀金属支架可以有效治疗胆道狭窄。然而，这些支架不可降解且易于再狭窄。在疾病缓解或再狭窄的情况下，需要通过手术取出或更换不可降解支架。为克服这些缺点，人们对支架所用材料和表面进行了改进。首先，本文回顾了不可降解支架的优缺点。其次，重点介绍了可生物降解聚合物和可生物降解金属支架以及功能性涂层。这也包括组织工程和3D打印支架。最后，讨论了胆道支架的未来前景，包括促上皮化涂层、多功能涂层支架、可生物降解形状记忆支架和4D生物打印。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/8d587f34031b/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/0468175798ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/aec55474501e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/62639c9a3300/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/f5f3a00fb94a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/eb06e90a8be0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/4cd0feae473b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/cb04242ca249/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/c4c330a310a4/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/60950a3dd6df/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/b5cc77d96ff5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/63b80656df75/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/c73f27846698/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/d0410a2f14a0/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/53617b0b6f2c/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/8d587f34031b/gr15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/0468175798ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/aec55474501e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/62639c9a3300/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/f5f3a00fb94a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/eb06e90a8be0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/4cd0feae473b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/cb04242ca249/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/c4c330a310a4/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/60950a3dd6df/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/b5cc77d96ff5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/63b80656df75/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/c73f27846698/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/d0410a2f14a0/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/53617b0b6f2c/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d22/11417150/8d587f34031b/gr15.jpg

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Biliary stents for active materials and surface modification: Recent advances and future perspectives.

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引用本文的文献

[1]
Prevention of stent migration of covered self-expandable metal stents in distal malignant biliary obstruction: a review of literature.

Gastroenterol Rep (Oxf). 2025-6-29

[2]
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[3]
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[4]
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[5]
Recent research progresses of bioengineered biliary stents.

Mater Today Bio. 2024-10-5

本文引用的文献

[1]
4D Printing for Biomedical Applications.

Adv Mater. 2024-8

[2]
Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer.

NPJ Biofilms Microbiomes. 2024-3-30

[3]
3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation.

Bioact Mater. 2024-3-21

[4]
Percutaneous placement of a retrievable fully covered metal stent with anchoring flaps for the treatment of biliary anastomotic stricture following LDLT.

J Int Med Res. 2024-3

[5]
Anti-fibrotic and anti-stricture effects of biodegradable biliary stents braided with dexamethasone-impregnated sheath/core structured monofilaments.

Acta Biomater. 2024-4-1

[6]
Prospective study on planned biliary stent placement to treat small common bile duct stones.

JGH Open. 2024-2-23

[7]
Endoscopic Management of Difficult Biliary Stones: An Evergreen Issue.

Medicina (Kaunas). 2024-2-19

[8]
Methods to improve antibacterial properties of PEEK: A review.

Biomed Mater. 2024-2-29

[9]
Structural and temporal dynamics analysis of zinc-based biomaterials: History, research hotspots and emerging trends.

Bioact Mater. 2024-2-10

[10]
Advances in targeted therapy of cholangiocarcinoma.

Ann Med. 2024-12

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