Meador K J, Loring D W, King D W, Gallagher B B, Gould M J, Smith J R, Flanigin H F
Department of Neurology, Medical College of Georgia, Augusta 30912.
Int J Neurosci. 1988 Feb;38(3-4):407-14. doi: 10.3109/00207458808990701.
Limbic evoked potentials (LEPs) were recorded from the hippocampi of three epilepsy surgery patients with unilateral medial temporal lobe seizure onset. In each patient, stable large amplitude LEPs which displayed polarity inversion across successive levels of hippocampus were present unilaterally, but were absent or rudimentary in the hippocampus corresponding to the electrographically proven seizure onset. After administration of scopolamine, LEPs in the "normal" hippocampi were markedly altered with slowing of the individual components and increased trial to trial variability. In addition, two patients developed reliable, high amplitude, polarity inverting LEPs on the side of seizure onset which had either absent or rudimentary LEPs in the baseline state. The results suggest that LEPs are under cholinergic modulation.
从三名单侧内侧颞叶癫痫发作起始的癫痫手术患者的海马体记录了边缘叶诱发电位（LEP）。在每名患者中，单侧出现了稳定的大幅度LEP，其在海马体的连续层面上显示出极性反转，但在与脑电图证实的癫痫发作起始相对应的海马体中不存在或很微弱。给予东莨菪碱后，“正常”海马体中的LEP明显改变，各成分减慢，每次试验间的变异性增加。此外，两名患者在癫痫发作起始侧出现了可靠的、高幅度的、极性反转的LEP，而在基线状态下该侧的LEP不存在或很微弱。结果表明LEP受胆碱能调节。
