Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, United States of America.
Department of Clinical Psychology, Teachers College, Columbia University, New York, NY, United States of America.
Clin Psychol Rev. 2021 Apr;85:102000. doi: 10.1016/j.cpr.2021.102000. Epub 2021 Mar 1.
There has been a marked increase of network studies of Major Depressive Disorder (MDD). Despite rapidly growing contributions, their findings have yet to be systematically aggregated and examined. We therefore conducted a systematic review of depression network studies using PRISMA guidelines. A total of 254 clinical and population studies were collected from ISI's Web of Science and PsycINFO, between January 2010 to May 2020. A total of 23 between-subject studies were included for review, resulting in 58 cross-sectional networks. To determine their most critical symptoms and their connections, we analyzed strength centrality rankings, and aggregated the most robust symptoms connections into a summary network. Results indicated substantial variability between study samples, depression measures, and network features. Fatigue and Depressed Mood were the most central symptoms, while Weight changes tended to have the weakest centrality. Depressed Mood and Fatigue formed two separated symptoms communities characterized by recurrent connections, with Mood-Anhedonia as the most frequent edge of MDD. Network analysis informed our understanding of MDD, suggesting the critical role of Fatigue and Depressed Mood. The study's findings are discussed in their clinical and methodological implications, including future directions for network studies of MDD.
目前已经有大量针对重度抑郁症（MDD）的网络研究。尽管研究贡献迅速增加，但它们的研究结果尚未被系统地综合和检验。因此，我们按照 PRISMA 指南对抑郁症网络研究进行了系统回顾。这项研究共从 ISI 的 Web of Science 和 PsycINFO 数据库中收集了 2010 年 1 月至 2020 年 5 月期间的 254 项临床和人群研究。共纳入 23 项组间研究进行综述，得到了 58 个横断面网络。为了确定它们最关键的症状及其联系，我们分析了强度中心性排名，并将最稳健的症状联系汇总到一个总结网络中。结果表明，研究样本、抑郁测量和网络特征之间存在很大的可变性。疲劳和情绪低落是最核心的症状，而体重变化的中心性往往最弱。情绪低落和疲劳形成了两个以反复连接为特征的分离症状群，其中情绪快感缺失是 MDD 最常见的连接。网络分析使我们对 MDD 有了更深入的了解，表明疲劳和情绪低落起着关键作用。本文讨论了这些发现的临床和方法学意义，包括未来 MDD 网络研究的方向。
