Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010059, China.
Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010059, China.
Eur J Radiol. 2021 May;138:109622. doi: 10.1016/j.ejrad.2021.109622. Epub 2021 Mar 6.
To evaluate the diagnostic -->performance of mean apparent propagator-magnetic resonance imaging (MAP-MRI) in distinguishing the grades of diffuse gliomas.
Thirty-six patients with pathologically confirmed diffuse gliomas were enrolled in this study. MAP-MRI parameters were measured in the parenchymal area of the tumour: non-Gaussianity (NG), non-Gaussianity axial (NGAx), non-Gaussianity vertical (NGRad), Q-space inverse variance (QIV), return to the origin probability (RTOP), return to the axis probability (RTAP), return to the plane probability (RTPP), and mean square displacement (MSD). Differences in the parameters between any two grades were compared, the characteristics of the parameters for different diffuse glioma grades were analysed, and receiver operating characteristic (ROC) curves were plotted to analyse the diagnostic value of each parameter.
Compared with grade III gliomas, grade II gliomas had lower NG, NGAx and NGRad values. NG, NGAx and NGRad had great area under the ROC curve (AUC) values (0.823, 0.835, and 0.838, P < 0.05). Compared with those of grade IV glioma, the NG, NGAx, NGRad, RTAP and RTOP values for grade II glioma were lower, the QIV values were higher (all P < 0.05). NG, NGAx, NGRad, RTAP, RTOP and QIV had great area under the ROC curve (AUC) values (0.923, 0.929, 0.923,0.793,0.822, and 0.769, P < 0.05).
Quantitative MAP-MRI parameters can distinguish grade II and III and grade II and IV gliomas before surgery but not grade III and IV gliomas. Thus, these parameters have clinical guiding value in the noninvasive preoperative evaluation of tumour pathological grading.
评估平均表观扩散系数-磁共振成像（MAP-MRI）在鉴别弥漫性胶质瘤分级中的诊断性能。
本研究纳入了 36 例经病理证实的弥漫性胶质瘤患者。在肿瘤实质区域测量 MAP-MRI 参数：非高斯性（NG）、非高斯性轴向（NGAx）、非高斯性垂直（NGRad）、Q 空间倒数方差（QIV）、返原点概率（RTOP）、返轴概率（RTAP）、返平面概率（RTPP）和均方根位移（MSD）。比较任意两级之间参数的差异，分析各参数在不同弥漫性胶质瘤分级中的特征，并绘制受试者工作特征（ROC）曲线分析各参数的诊断价值。
与 3 级胶质瘤相比，2 级胶质瘤的 NG、NGAx 和 NGRad 值较低。NG、NGAx 和 NGRad 的 ROC 曲线下面积（AUC）值较大（0.823、0.835 和 0.838，P<0.05）。与 4 级胶质瘤相比，2 级胶质瘤的 NG、NGAx、NGRad、RTAP 和 RTOP 值较低，QIV 值较高（均 P<0.05）。NG、NGAx、NGRad、RTAP、RTOP 和 QIV 的 ROC 曲线下面积（AUC）值较大（0.923、0.929、0.923、0.793、0.822 和 0.769，P<0.05）。
定量 MAP-MRI 参数可在术前区分 2 级和 3 级以及 2 级和 4 级胶质瘤，但不能区分 3 级和 4 级胶质瘤。因此，这些参数在肿瘤病理分级的无创术前评估中具有临床指导价值。
