白细胞介素-33 水平与慢性阻塞性肺疾病急性加重的相关性。
Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease.
机构信息
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
出版信息
BMC Pulm Med. 2021 Mar 15;21(1):86. doi: 10.1186/s12890-021-01423-8.
BACKGROUND
The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD.
METHODS
Plasma IL-33 was measured in 62 COPD patients during their stable state. Patients were prospectively followed up for 1 year. The expression of IL-33 was measured in lung tissue obtained from 38 patients who underwent surgery.
RESULTS
The number of exacerbations was significantly higher in the high plasma IL-33 group compared with the low plasma IL-33 group. On Poisson regression analysis, high plasma IL-33 was associated with increased risk of exacerbation (incidence rate ratio = 2.166, P = 0.043). The expression of IL-33 in the lung was higher in COPD patients than in controls. The expression of IL-33 was significantly correlated with smoking pack years (R = 0.45, P < 0.01) and Forced expiratory volume in 1 s (%) (R = - 0.58, P < 0.01).
CONCLUSION
The plasma level of IL-33 in patients with COPD was significantly associated with the risk of exacerbation in prospective follow up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function.
背景
白细胞介素 (IL)-33 在慢性阻塞性肺疾病 (COPD) 患者中的作用尚未得到充分阐明。本研究旨在分析血浆 IL-33 水平与 COPD 急性加重的关系。
方法
在稳定期测量 62 例 COPD 患者的血浆 IL-33。前瞻性随访患者 1 年。测量了 38 例接受手术的患者肺组织中的 IL-33 表达。
结果
高血浆 IL-33 组的加重次数明显高于低血浆 IL-33 组。泊松回归分析显示，高血浆 IL-33 与加重风险增加相关（发生率比=2.166，P=0.043）。COPD 患者肺组织中 IL-33 的表达高于对照组。IL-33 的表达与吸烟包年数呈正相关（R=0.45，P<0.01），与 1 秒用力呼气量（FEV1）%呈负相关（R=-0.58，P<0.01）。
结论
COPD 患者血浆 IL-33 水平与前瞻性随访中加重的风险显著相关。肺组织中 IL-33 的表达与吸烟呈正相关，与肺功能呈负相关。
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