Leibovici L, Sharir T, Kalter-Leibovici O, Alpert G, Epstein L M
Israel Defence Forces Medical Corps, Beilinson Medical Center, Petah Tiqva.
J Adolesc Health Care. 1988 May;9(3):203-7. doi: 10.1016/0197-0070(88)90072-1.
We report the clinical and laboratory characteristics of measles infection in an unselected group of 461 young adults. Otitis media was diagnosed in 9.8%, sinusitis in 4.1%, pneumonia in 3.7%, and keratitis in 3.3% of the patients. Minor T-wave changes on electrocardiogram were observed in only 0.7% and jaundice in 0.4%. Elevated liver enzymes were found in 51% of the patients. Creatine kinase (CK) MM fraction was high in 44%. Traces of myoglobin were found in the urine of 14% of those with a high CK, and of the 13 patients with the higher CKs, 12 had an abnormal serum aldolase. We emphasize several points of interest in this large and unselected group of young adults. There was 1) possible evidence of rhabdomyolisis in some of our patients; 2) a lower rate of electrocardiogram abnormalities than previously reported; 3) no evident correlation between initial laboratory values and subsequent complications; and 4) lack of a clinical or laboratory difference between patients who had been vaccinated with an attenuated virus during childhood and those who had not.
我们报告了461名未经过挑选的年轻成人麻疹感染的临床和实验室特征。9.8%的患者被诊断为中耳炎，4.1%为鼻窦炎，3.7%为肺炎，3.3%为角膜炎。仅0.7%的患者心电图出现轻微T波改变，0.4%出现黄疸。51%的患者肝酶升高。44%的患者肌酸激酶（CK）MM组分升高。在CK升高的患者中，14%的患者尿中发现微量肌红蛋白，在13例CK更高的患者中，12例血清醛缩酶异常。我们强调了在这一大组未经挑选的年轻成人中几个有趣的点。1）我们的一些患者可能有横纹肌溶解的证据；2）心电图异常发生率低于先前报道；3）初始实验室值与随后并发症之间无明显相关性；4）童年时期接种减毒活疫苗的患者与未接种的患者在临床或实验室方面无差异。
