Hondalus M K, Lofstedt J
Department of Large Animal Medicine, School of Veterinary Medicine, Tufts University, Grafton, MA 01536.
J Am Vet Med Assoc. 1988 Feb 15;192(4):527-9.
A 16-year-old pony with signs of intermittent abdominal pain was treated with phenylbutazone in excess of the recommended dosage. Endoscopy revealed ulceration of the esophagus, stomach, and proximal portion of small intestine. The pony developed diarrhea. Salmonella typhimurium was isolated from the blood and feces. Treatment included fluids, trimethoprim-sulfadiazine, sucralfate, and ranitidine hydrochloride. The diarrhea resolved, as did the gastrointestinal ulceration. This case was unusual because septicemia with salmonellosis is an uncommon finding in adult equids. Also, complications commonly seen in neonatal septicemia (septic arthritis, nephritis, and hepatitis) were not observed. Phenylbutazone toxicosis and stress were considered possible causes for the gastrointestinal ulceration.
一匹16岁的矮种马出现间歇性腹痛症状，接受了超过推荐剂量的保泰松治疗。内窥镜检查发现食管、胃和小肠近端有溃疡。这匹矮种马出现了腹泻。从血液和粪便中分离出鼠伤寒沙门氏菌。治疗措施包括补液、甲氧苄啶磺胺嘧啶、硫糖铝和盐酸雷尼替丁。腹泻和胃肠道溃疡都得到了缓解。该病例不同寻常，因为成年马属动物中沙门氏菌病败血症并不常见。此外，未观察到新生儿败血症常见的并发症（化脓性关节炎、肾炎和肝炎）。保泰松中毒和应激被认为是胃肠道溃疡的可能原因。
