Klyushova Lyubov S, Perepechaeva Maria L, Grishanova Alevtina Y
Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, 630117 Novosibirsk, Russia.
Biomedicines. 2022 Oct 24;10(11):2686. doi: 10.3390/biomedicines10112686.
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes' activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases.
细胞色素P450（CYP）超家族中的CYP3A是一个酶亚家族，包括CYP3A4、CYP3A5、CYP3A7和CYP3A43同工型。CYP3A酶对底物没有选择性，其独特之处在于这些酶既能代谢内源性化合物，也能代谢多种外源性物质（包括药物）；这些化合物几乎唯一的共同特征是亲脂性和相对较大的分子量。CYP3A酶在人体器官和组织中广泛表达，这些酶活性的结果在正常调节内源性化合物的生理水平以及各种病理状况中都起着重要作用。本综述阐述了生理条件下CYP3A酶的调节的这些方面及其在疾病发生和发展中的作用。
