Active Ageing Research Group, Institute of Health, University of Cumbria, Lancaster, UK.
Translational Physiology Research Group, School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, 115 New Cavendish St, London, W1W 6UW, UK.
Eur J Appl Physiol. 2021 Jul;121(7):1909-1919. doi: 10.1007/s00421-021-04635-2. Epub 2021 Mar 16.
The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s 'all out' static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men.
Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group.
Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL and 60 (12) pg mL, respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL which was similar to that of young men who did not undergo training (p = 0.113, Cohen's d = 1.07).
Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans, the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.
本研究旨在探讨年龄对循环前炎症细胞因子和生长因子的影响。次要目的是研究一种新的冲刺间歇训练（SIT）干预措施（每周两次，每次 3 次×20 秒“全力以赴”的静态冲刺，共 8 周）是否会影响老年男性的炎症标志物。
年轻组包括 9 名老年男性（68[1]岁）和 11 名年轻男性（28[2]岁）。两组均在基线时测量有氧健身和炎症标志物，然后对老年组进行 SIT 干预。
IL-8、血管内皮生长因子（VEGF）和单核细胞趋化蛋白-1（MCP-1）在老年组和年轻组的基线时均无变化（IL-8，p=0.819；MCP-1，p=0.248；VEGF，p=0.264）。与年轻组相比，老年组的表皮生长因子（EGF）在基线时更高[分别为 142（20）pg/mL 和 60（12）pg/mL，p=0.001，Cohen's d=1.64]。SIT 后，老年男性的 EGF 降至 100（12）pg/mL，与未接受训练的年轻男性相似（p=0.113，Cohen's d=1.07）。
经过有氧训练的老年男性的血清 EGF 高于年轻的有氧训练男性。老年男性新的 SIT 干预可以使循环中的 EGF 向受过训练的年轻浓度转移。由于先前较低的 EGF 与秀丽隐杆线虫的长寿有关，因此 SIT 对人类健康衰老中 EGF 的操纵作用可能会引起进一步的兴趣。
