Department of Physiology, Academy of Physical Education in Katowice, Katowice, Poland.
School of Medicine with the Division of Dentistry, Department of Lung Disease and Tuberculosis, Medical University of Silesia, 1 Koziołka St. 41-803 Zabrze, Katowice, Poland.
Biomed Res Int. 2019 Sep 22;2019:7315714. doi: 10.1155/2019/7315714. eCollection 2019.
The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers.
Twelve physically active male subjects completed a high-intensity interval training (HIIT) in normoxia (NorTr) and in normobaric hypoxia (HypTr) (FiO = 15.2%). The effects of HIIT in hypoxia and normoxia on maximal oxygen uptake, hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, nitric oxide, and cytokines were analyzed.
HIIT in hypoxia significantly increases maximal oxygen uptake (=0.01) levels compared to pretraining levels. Serum hypoxia-inducible factor-1 (=0.01) and nitric oxide levels (=0.05), vascular endothelial growth factor (=0.04), and transforming growth factor- (=0.01) levels were increased in response to exercise test after hypoxic training. There was no effect of training conditions for serum baseline angiogenic factors and cytokines ( > 0.05) with higher HIF-1 and NO levels after hypoxic training compared to normoxic training ( = 9.1; < 0.01 and = 5.7; < 0.05, respectively).
High-intensity interval training in hypoxia seems to induce beneficial adaptations to exercise mediated via a significant increase in the serum concentrations of proangiogenic factors and serum nitric oxide levels compared to the same training regimen in normoxia.
本研究旨在探讨在常氧和低氧条件下进行高强度间歇训练对健康男性志愿者血清中促血管生成因子、一氧化氮和炎症反应的影响。
12 名有运动习惯的男性志愿者分别在常氧（NorTr）和常压低氧（HypTr）条件下（FiO₂=15.2%）完成高强度间歇训练（HIIT）。分析 HIIT 在低氧和常氧条件下对最大摄氧量、缺氧诱导因子-1α、血管内皮生长因子、一氧化氮和细胞因子的影响。
与训练前相比，低氧 HIIT 显著提高了最大摄氧量（=0.01）水平。血清缺氧诱导因子-1（=0.01）和一氧化氮水平（=0.05）、血管内皮生长因子（=0.04）和转化生长因子-β（=0.01）水平在低氧训练后的运动测试中升高。与常氧训练相比，训练条件对血清基线血管生成因子和细胞因子无影响（>0.05），但低氧训练后的 HIF-1 和 NO 水平更高（=9.1；<0.01 和=5.7；<0.05）。
与相同的常氧训练方案相比，低氧条件下的高强度间歇训练似乎通过显著增加血清中促血管生成因子和一氧化氮水平，对运动介导的适应性产生有益影响。
