Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
Acta Physiol (Oxf). 2021 May;232(1):e13644. doi: 10.1111/apha.13644. Epub 2021 Mar 16.
Humans are exposed to varying amounts of ultraviolet radiation (UVR) through sunlight. UVR penetrates into human skin leading to release of neuropeptides, neurotransmitters and neuroendocrine hormones. These messengers released from local sensory nerves, keratinocytes, Langerhans cells (LCs), mast cells, melanocytes and endothelial cells (ECs) modulate local and systemic immune responses, mediate inflammation and promote differing cell biologic effects. In this review, we will focus on both animal and human studies that elucidate the roles of calcitonin gene-related peptide (CGRP), substance P (SP), nerve growth factor (NGF), nitric oxide and proopiomelanocortin (POMC) derivatives in mediating immune and inflammatory effects of exposure to UVR as well as other cell biologic effects of UVR exposure.
人类通过阳光暴露于不同量的紫外线辐射 (UVR)。UVR 穿透入人类皮肤导致神经肽、神经递质和神经内分泌激素的释放。这些从局部感觉神经、角质形成细胞、朗格汉斯细胞 (LCs)、肥大细胞、黑素细胞和内皮细胞 (ECs) 释放的信使调节局部和全身免疫反应、介导炎症并促进不同的细胞生物学效应。在这篇综述中，我们将重点关注阐明降钙素基因相关肽 (CGRP)、P 物质 (SP)、神经生长因子 (NGF)、一氧化氮和促黑皮质素原 (POMC) 衍生物在介导 UVR 暴露的免疫和炎症效应以及 UVR 暴露的其他细胞生物学效应方面的动物和人体研究。
