Misery L
Department of Dermatology, University Hospital, Saint-Etienne, France.
Photodermatol Photoimmunol Photomed. 2000 Apr;16(2):78-81. doi: 10.1034/j.1600-0781.2000.d01-8.x.
Numerous cells are closely associated with cutaneous nerve fibers, which through the action of neuropeptides are able to modulate cellular function. Anatomical and physiological links between immune cells and nerves and other cells in skin are so close that we propose the concept of a neuro-immuno-cutaneous system (NICS). Under the impact of ultraviolet radiation (UVR) virtually all properties of the NICS are modified. UVR induces melanin synthesis and immunosuppression, events in which neuropeptides, especially melanocyte stimulating hormone (MSH) and the calcitonin gene-related peptide CGRP, play a role.
许多细胞与皮肤神经纤维紧密相连，这些神经纤维通过神经肽的作用能够调节细胞功能。免疫细胞与皮肤中的神经及其他细胞之间的解剖学和生理学联系非常紧密，因此我们提出了神经免疫皮肤系统（NICS）这一概念。在紫外线辐射（UVR）的影响下，NICS的几乎所有特性都会发生改变。UVR会诱导黑色素合成和免疫抑制，神经肽尤其是促黑素（MSH）和降钙素基因相关肽（CGRP）在这些过程中发挥作用。
