Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.
Universitat Rovira i Virgili, Departament de Química Analítica i Química Orgànica, c/Marcel·lí Domingo 1, 43007, Tarragona, Spain.
J Am Chem Soc. 2021 Apr 7;143(13):4949-4954. doi: 10.1021/jacs.1c01916. Epub 2021 Mar 16.
A Ni-catalyzed reductive carboxylation of substituted aziridines with CO at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.
本文公开了一种在常压下使用 CO 对取代氮丙啶进行镍催化还原羧化的方法。该方法具有条件温和、实验操作简便以及出色的化学和区域选择性等特点，为构建β-氨基酸提供了一种新的催化蓝图，β-氨基酸作为具有巨大应用潜力的肽类似物的重要构建模块。
