Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
Chem Commun (Camb). 2021 Apr 18;57(30):3696-3699. doi: 10.1039/d1cc00202c. Epub 2021 Mar 16.
This paper describes the synthesis of unsymmetrical biaryls by the palladium-catalyzed cross-coupling reaction of acyl chlorides with potassium perfluorobenzoates. This transformation is unique in that it involves simultaneous decarbonylation and decarboxylation under redox-neutral conditions. Compared to conventional cross-coupling protocols for the synthesis of unsymmetrical biaryls, the two reactants in this synthetic strategy can be readily prepared from abundant and inexpensive aromatic carboxylic acids.
本文描述了通过钯催化的酰氯与全氟苯甲酸钾的交叉偶联反应合成不对称联苯。这种转化的独特之处在于它在氧化还原中性条件下同时涉及脱羰和脱羧。与传统的合成不对称联苯的交叉偶联方案相比，这种合成策略中的两种反应物可以很容易地从丰富且廉价的芳香羧酸制备得到。
