Pd(0)催化的脱羧偶联和串联 C-H 芳基化/脱羧反应合成杂芳基联芳烃。
Pd(0)-catalyzed decarboxylative coupling and tandem C-H arylation/decarboxylation for the synthesis of heteroaromatic biaryls.
机构信息
Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan, R.O.C.
出版信息
J Org Chem. 2012 Oct 19;77(20):9384-90. doi: 10.1021/jo3015837. Epub 2012 Oct 2.
PMID:22998080
Abstract
An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo[1,2-a]pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C-H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.
摘要
一种有效的 Pd(0)卡宾配合物被成功应用于杂芳基羧酸（咪唑并[1,2-a]吡啶和异恶唑）与芳基卤化物的脱羧偶联反应。对于羧基吲哚，发生脱羧偶联或串联 C-H 芳基化和脱羧反应，生成 C2-单芳基化的吲哚。
Zotero 插件