Pan Fei, Boursalian Gregory B, Ritter Tobias
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim an der Ruhr, Germany.
Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16871-16876. doi: 10.1002/anie.201811139. Epub 2018 Nov 16.
Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro-, and materials chemistry. A palladium-catalyzed decarbonylative cross-coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.
尽管二氟甲基在医学、农业和材料化学中具有重要性，但直接合成二氟甲基化芳烃的方法却很少。实现了钯催化的酰氯与二氟甲基锌试剂的脱羰交叉偶联反应，以制备二氟甲基化化合物。该转化反应在室温下进行，并且对官能团具有广泛的耐受性，从而为多种芳香族羧酸的脱羰二氟甲基化提供了一种通用且高效的方法。
