Neumann Samantha N, Li Jun-Juan, Yuan Xiao-Dong, Chen Shuo-Hua, Ma Chao-Ran, Murray-Kolb Laura E, Shen Yun, Wu Shou-Ling, Gao Xiang
Eberly College of Science, The Pennsylvania State University, University Park, PA, United States.
West Virginia School of Osteopathic Medicine, Lewisburg, WV, United States.
Chin Med J (Engl). 2020 Dec 21;134(6):675-681. doi: 10.1097/CM9.0000000000001306.
Several recent genome-wide association studies suggested insomnia and anemia may share some common genetic components. We thus examined whether adults with anemia had higher odds of having insomnia relative to those without anemia in a cross-sectional study and a meta-analysis.
Included in this cross-sectional study were 12,614 Chinese adults who participated in an ongoing cohort, the Kailuan Study. Anemia was defined as hemoglobin levels below 12.0 g/dL in women and 13.0 g/dL in men. Insomnia was assessed using the Chinese version of the Athens Insomnia Scale (AIS). A total AIS score ≥6 was considered insomnia. The association between anemia and insomnia was assessed using a logistic regression model, adjusting for potential confounders such as age, sex, chronic disease status, and plasma C-reactive protein concentrations. A meta-analysis was conducted using the fixed effects model to pool results from our study and three previously published cross-sectional studies on this topic in adult populations.
Individuals with anemia had greater odds of having insomnia (adjusted odds ratio [OR]: 1.32; 95% confidence interval [CI]: 1.03-1.70) compared with individuals without anemia. A significant association persisted after we excluded individuals with chronic inflammation, as suggested by C-reactive protein levels >1 mg/L (adjusted OR: 1.68; 95% CI: 1.22-2.32). The meta-analysis results, including 22,134 participants, also identified a positive association between anemia and insomnia (pooled OR: 1.39; 95% CI: 1.22-1.57).
The presence of anemia was significantly associated with a higher likelihood of having insomnia in adults. Due to the nature of the cross-sectional study design, results should be interpreted with caution.
近期多项全基因组关联研究表明，失眠和贫血可能共享一些共同的遗传成分。因此，我们在一项横断面研究和荟萃分析中，考察了贫血成年人相对于非贫血成年人患失眠症的几率是否更高。
这项横断面研究纳入了12,614名参与开滦队列研究的中国成年人。贫血定义为女性血红蛋白水平低于12.0 g/dL，男性低于13.0 g/dL。使用中文版雅典失眠量表（AIS）评估失眠情况。AIS总分≥6分被视为失眠。采用逻辑回归模型评估贫血与失眠之间的关联，并对年龄、性别、慢性病状况和血浆C反应蛋白浓度等潜在混杂因素进行校正。使用固定效应模型进行荟萃分析，汇总我们的研究结果以及之前发表的三项关于该主题的成人横断面研究结果。
与非贫血个体相比，贫血个体患失眠症的几率更高（校正比值比[OR]：1.32；95%置信区间[CI]：1.03 - 1.70）。正如C反应蛋白水平>1 mg/L所提示的，排除患有慢性炎症的个体后，显著关联依然存在（校正OR：1.68；95% CI：1.22 - 2.32）。荟萃分析结果纳入了22,134名参与者，也确定了贫血与失眠之间存在正相关（合并OR：1.39；95% CI：1.22 - 1.57）。
贫血与成年人患失眠症的较高可能性显著相关。由于横断面研究设计的性质，对结果的解释应谨慎。
