Beijing University of Chinese Medicine, Beijing.
Chengdu University of Chinese Medicine, Chengdu.
Medicine (Baltimore). 2021 Mar 12;100(10):e18621. doi: 10.1097/MD.0000000000018621.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with increasing incidence. The externalizing and internalizing problems among children with ASD often persistent and highly impair functioning of both the child and the family. Children with ASD often develop gut-related comorbidities and dysbiosis can have negative effects on not only the gastrointestinal (GI) tract, but also psychological symptoms. Dietary exclusions and probiotic supplements also have been investigated in the management of ASD symptoms. Especially, there is some anecdotal evidence that probiotics supplements are able to alleviate GI symptoms as well as improve behaviors in children with ASD.
This review will report on overall studies that include randomized control trials, randomized cross-over studies and cluster-randomized trials designs that consider curative effect in children with ASD by probiotic supplements. We will search 6 databases: MEDLINE, Embase, Scopus, PubMed, The Cochrane Library, and Web of Science and we will perform a manual search the journal Autism and information of ongoing or unpublished studies. The Mixed Methods Appraisal Tool (MMAT) will be used to assess quality of articles and the Jadad scale will be used to assess for bias. Assessment of publication bias will be performed using funnel plots generated by Comprehensive Meta-Analysis (CMA) 3.0 software. Clarifying the evidence in this area will be important for future research directions when reformulating and promoting the therapeutic regime in the field.
There are no human participants, data, or tissue being directly studied for the purposes of the review; therefore, ethics approval and consent to participate are not applicable. The results of this study will be presented at conferences and published in peer-reviewed journals.
PROSPERO 2019 CRD42019132754.
自闭症谱系障碍（ASD）是一种神经发育障碍，其发病率不断增加。自闭症儿童的外在和内在问题往往持续存在，严重影响儿童及其家庭的功能。自闭症儿童常伴有肠道相关并发症，肠道菌群失调不仅会对胃肠道（GI）产生负面影响，还会导致心理症状。饮食排除和益生菌补充剂也被用于 ASD 症状的管理。特别是，有一些轶事证据表明，益生菌补充剂能够缓解 GI 症状，并改善自闭症儿童的行为。
本综述将报告总体研究，包括随机对照试验、随机交叉试验和整群随机试验设计，这些研究通过益生菌补充剂考虑 ASD 儿童的疗效。我们将检索 6 个数据库：MEDLINE、Embase、Scopus、PubMed、Cochrane 图书馆和 Web of Science，并将对自闭症期刊和正在进行或未发表研究的信息进行手动搜索。混合方法评估工具（MMAT）将用于评估文章的质量，Jadad 量表将用于评估偏倚。使用综合荟萃分析（CMA）3.0 软件生成的漏斗图来评估发表偏倚。澄清这一领域的证据对于未来的研究方向非常重要，有助于在该领域重新制定和推广治疗方案。
本综述不涉及人类参与者、数据或组织，因此不适用伦理批准和参与同意。这项研究的结果将在会议上展示，并发表在同行评议的期刊上。
PROSPERO 2019 CRD42019132754。
