干扰素可诱导艾氏腹水瘤细胞培养物发生细胞融合并形成多核细胞。
Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells.
作者信息
Tominaga S
机构信息
Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
出版信息
J Cell Physiol. 1988 May;135(2):350-4. doi: 10.1002/jcp.1041350225.
PMID:3372601
Abstract
The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.
摘要
当细胞培养物用1000 IU/ml的重组小鼠α或β干扰素（IFN）处理时，艾氏腹水瘤（EAT）细胞数量的增加显著减少。显微镜观察显示，在IFN处理后3至5天，几乎所有细胞都呈现双核或多核形态。此外，一段视频记录显示，每个多核细胞是由一个亲代细胞有丝分裂后融合产生的。
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