Department of Pediatrics, The First Hospital of Hebei Medical University.
Department of Thoracic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Medicine (Baltimore). 2021 Mar 19;100(11):e25195. doi: 10.1097/MD.0000000000025195.
The present study was conducted with an attempt to explore the correlation of serum resistin level and other metabolic hormones and immune function in neonatal umbilical cord blood.The levels of umbilical cord blood resistin, adiponectin, insulin, growth hormone, leptin, thyrotropin, thyroid hormone (T3, T4), lgM, lgA, lgG, CD4, and CD8 were measured in 180 full-term newborns delivered in hospital from October 2018 to November 2019. The delivery mode, weight, height, and gender at birth were recorded.The levels of resistin, insulin, and growth hormone in umbilical cord blood of newborns delivered vaginally were significantly higher than those born by cesarean section (P < .05), while the levels of adiponectin, leptin, TST, T3, T4, lgM, lgA, lgG, CD4, and CD8 were comparable between the 2 groups (P > .05). The levels of resistin, adiponectin, insulin, growth hormone, leptin, TST, T3, T4, lgM, lgA, lgG, CD4, and CD8 in cord blood of male and female newborns were comparable (P > .05). The newborns with birth weight ≥ 3501 g reported comparable results in the levels of resistin and growth hormone compared with those with birth weight of 3000 to 3500 g (P > .05), but were significantly higher than those with birth weight ≤ 2999 g (P < 0.05). In addition, the levels of adiponectin, insulin, leptin, TST, T3, T4, lgM, lgA, lgG, CD4, and CD8 were comparable among the 3 groups (P > .05). Based on Pearson correlation analysis, neonatal umbilical cord blood resistin was positively correlated with adiponectin, leptin, growth hormone, T3, and T4 (r = 0.281, 0.287, 0.321, 0.276, 0.269, P < .05). However, there was no significant correlation between neonatal umbilical cord blood resistin and insulin, TST, lgM, lgA, lgG, CD4, and CD8.The level of serum resistin in neonatal umbilical cord blood was associated with the delivery mode and birth weight, and positively correlated with adiponectin, leptin, growth hormone, T3, and T4. However, no correlation was observed between serum resistin in neonatal umbilical cord blood and insulin, TST, lgM, lgA, lgG, CD4, and CD8.
本研究旨在探讨新生儿脐血抵抗素水平与其他代谢激素和免疫功能的相关性。选取 2018 年 10 月至 2019 年 11 月在我院分娩的 180 例足月新生儿，记录其分娩方式、出生体重、身高及性别，采用酶联免疫吸附法检测脐血抵抗素、脂联素、胰岛素、生长激素、瘦素、促甲状腺激素、甲状腺激素（T3、T4）、免疫球蛋白 M（lgM）、免疫球蛋白 A（lgA）、免疫球蛋白 G（lgG）、CD4、CD8 水平。结果显示，阴道分娩新生儿脐血抵抗素、胰岛素、生长激素水平显著高于剖宫产新生儿（P＜0.05），而脂联素、瘦素、促甲状腺激素、T3、T4、lgM、lgA、lgG、CD4、CD8 水平 2 组间比较差异无统计学意义（P＞0.05）；男、女新生儿脐血抵抗素、脂联素、胰岛素、生长激素、瘦素、促甲状腺激素、T3、T4、lgM、lgA、lgG、CD4、CD8 水平比较差异无统计学意义（P＞0.05）；出生体质量≥3501g 的新生儿抵抗素、生长激素水平与出生体质量 3000～3500g 的新生儿比较差异无统计学意义（P＞0.05），但显著高于出生体质量≤2999g 的新生儿（P＜0.05）；而脂联素、胰岛素、瘦素、促甲状腺激素、T3、T4、lgM、lgA、lgG、CD4、CD8 水平 3 组间比较差异无统计学意义（P＞0.05）。Pearson 相关性分析结果显示，新生儿脐血抵抗素与脂联素、瘦素、生长激素、T3、T4 呈正相关（r=0.281、0.287、0.321、0.276、0.269，P＜0.05），与胰岛素、促甲状腺激素、lgM、lgA、lgG、CD4、CD8 无相关性（P＞0.05）。结论：新生儿脐血抵抗素水平与分娩方式和出生体质量有关，与脂联素、瘦素、生长激素、T3、T4 呈正相关，与胰岛素、促甲状腺激素、lgM、lgA、lgG、CD4、CD8 无相关性。
