Marinoni Emanuela, Corona Giovanna, Ciardo Francesca, Letizia Claudio, Moscarini Massimo, Di Iorio Romolo
Centre for Scientific Research, San Pietro Hospital, Fatebenefratelli, Rome, Italy.
Front Biosci (Elite Ed). 2010 Jan 1;2(1):52-8. doi: 10.2741/e65.
The aim of this study was to investigate the interrelationship between leptin,adiponectin and resistin in the fetal and early postnatal period and the association of these hormones with anthropometric and metabolic indexes. Serum concentrations of leptin, adiponectin and resistin were measured in maternal and neonatal circulation at delivery and on the 3rd day after birth in 40 healthy newborns and their mothers Serum leptin levels were significantly higher in fetuses that in newborn infants on 3rd day after delivery, whereas concentration of adiponectin and resistin were maintained in either maternal and neonatal circulation after delivery. Leptin serum concentrations correlated with those of adiponectin in the fetal circulation, but not in neonatal life. On the other hand no correlation was found between leptin and resistin levels in cord blood, whereas a positive correlation between leptin and resistin concentrations was present in the neonatal circulation on 3rd day. Fetal leptin, adiponectin and resistin levels are largely independent of maternal influences and immediately after birth, important changes in the relation among adipokines occurred compared to intrauterine life.
本研究旨在探讨胎儿期及出生后早期瘦素、脂联素和抵抗素之间的相互关系，以及这些激素与人体测量和代谢指标的关联。对40名健康新生儿及其母亲在分娩时和出生后第3天的母血和新生儿血循环中瘦素、脂联素和抵抗素的血清浓度进行了测定。分娩后第3天，胎儿血清瘦素水平显著高于新生儿，而脂联素和抵抗素浓度在分娩后的母血和新生儿血循环中均保持稳定。瘦素血清浓度在胎儿血循环中与脂联素相关，但在新生儿期不相关。另一方面，脐血中瘦素与抵抗素水平无相关性，而出生后第3天新生儿血循环中瘦素与抵抗素浓度呈正相关。胎儿瘦素、脂联素和抵抗素水平在很大程度上不受母体影响，与宫内生活相比，出生后即刻脂肪因子之间的关系发生了重要变化。
