School of Biological Sciences, Universiti Sains Malaysia, Minden, Penang, Malaysia.
Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus, Kuala Terengganu, Terengganu, Malaysia.
Crit Rev Biotechnol. 2021 Jun;41(4):474-490. doi: 10.1080/07388551.2020.1869685. Epub 2021 Mar 16.
Polyhydroxyalkanoate (PHA) is a biogenic polymer that has the potential to substitute synthetic plastic in numerous applications. This is due to its unique attribute of being a biodegradable and biocompatible thermoplastic, achievable through microbial fermentation from a broad utilizable range of renewable resources. Among all the PHAs discovered, poly(3-hydroxybutyrate--4-hydroxybutyrate) [P(3HB--4HB)] stands out as a next generation healthcare biomaterial for having high biopharmaceutical and medical value since it is highly compatible to mammalian tissue. This review provides a critical assessment and complete overview of the development and trend of P(3HB--4HB) research over the last few decades, highlighting aspects from the microbial strain discovery to metabolic engineering and bioprocess cultivation strategies. The article also outlines the relevance of P(3HB--4HB) as a material for high value-added products in numerous healthcare-related applications.
聚羟基烷酸酯（PHA）是一种生物源聚合物，具有在众多应用中替代合成塑料的潜力。这是由于其独特的属性，即作为一种可生物降解和生物相容的热塑性塑料，通过微生物发酵从广泛可用的可再生资源中实现。在所有发现的 PHAs 中，聚（3-羟基丁酸酯-4-羟基丁酸酯）[P（3HB-4HB）]因其具有很高的生物制药和医学价值而成为下一代医疗保健生物材料，因为它与哺乳动物组织高度兼容。本文对过去几十年中 P（3HB-4HB）研究的发展和趋势进行了批判性评估和全面概述，突出了从微生物菌株发现到代谢工程和生物过程培养策略的各个方面。文章还概述了 P（3HB-4HB）作为许多与医疗保健相关的应用中高附加值产品的材料的相关性。
