Pospisilova Aneta, Vodicka Juraj, Trudicova Monika, Juglova Zuzana, Smilek Jiri, Mencik Premysl, Masilko Jiri, Slaninova Eva, Melcova Veronika, Kalina Michal, Obruca Stanislav, Sedlacek Petr
Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00 Brno, Czech Republic.
Polymers (Basel). 2022 May 13;14(10):2007. doi: 10.3390/polym14102007.
Films prepared from poly(3-hydroxybutyrate--4-hydroxybutyrate) copolymers produced by sp. H1 using an automatic film applicator were homogeneous and had a defined thickness, which allowed a detailed study of physicochemical properties. Their properties were compared with those of a poly (3-hydroxybutyrate) homopolymer film prepared by the same procedure, which proved to be significantly more crystalline by DSC and XRD. Structural differences between samples had a major impact on their properties. With increasing 4-hydroxybutyrate content, the ductility and release rate of the model hydrophilic active ingredient increased significantly. Other observed properties, such as the release of the hydrophobic active substance, the contact angle with water and ethylene glycol, or the surface morphology and roughness, were also affected by the composition. The identified properties predetermine these copolymers for wide use in areas such as biomedicine or smart biodegradable packaging for food or cosmetics. The big advantage is the possibility of fine-tuning properties simply by changing the fermentation conditions.
使用自动涂膜器由sp. H1生产的聚（3-羟基丁酸酯-4-羟基丁酸酯）共聚物制备的薄膜是均匀的，且具有确定的厚度，这使得能够对其物理化学性质进行详细研究。将它们的性质与通过相同程序制备的聚（3-羟基丁酸酯）均聚物薄膜的性质进行了比较，通过差示扫描量热法（DSC）和X射线衍射（XRD）证明后者的结晶度明显更高。样品之间的结构差异对其性质有重大影响。随着4-羟基丁酸酯含量的增加，模型亲水性活性成分的延展性和释放速率显著增加。其他观察到的性质，如疏水性活性物质的释放、与水和乙二醇的接触角，或表面形态和粗糙度，也受组成的影响。所确定的这些性质决定了这些共聚物在生物医学或食品或化妆品的智能可生物降解包装等领域的广泛应用。最大的优势是仅通过改变发酵条件就可以微调性质。
