Kale Mayura A, Shamkuwar Prashant B, Mourya Vishnukant K, Deshpande Aishwarya B, Shelke Priyanka A
Government College of Pharmacy, Osmanpura, Aurangabad-431 005, Maharashtra, India.
Curr Drug Discov Technol. 2022;19(1):e140122192307. doi: 10.2174/1570163818666210316114331.
For a decade, it has been observed that there is a remarkable decrease in the quantum of novel clinically approved drugs, in spite of modernization in the research and development process. We have highlighted repositioning of drugs as a methodology that has found new therapeutic implications for clinically approved drugs but with different indications. This can be considered as an upbringing strategy to deliver timely and cost-effective solutions, which still need exploration for getting over the shortage of novel drugs reaching the market. This review focuses on an activity-based drug repositioning approach, which is used to explore new uses of known drugs that are already approved for specific indications and are now being used for other indications on the basis that a single drug interacts with multiple targets. It also includes current research trends related to drug repositioning, which depends on strong knowledge of medicinal chemistry and involves elucidation of mechanisms of action and validation of novel targets. The review highlights the importance of computational tools and databases of various forms for drug repositioning purposes, which have enhanced the ability to pose reasonable and testable hypotheses. The critical nature of this aspect is obvious in cases where data gathered from in vitro, or animal models do not confirm in subsequent clinical trials. Hence, considering the positive outcomes of drug repositioning, it can be surmised that this approach can serve as a promising one that can develop into a robust drug discovery strategy.
十年来，人们观察到，尽管研发过程实现了现代化，但新的临床批准药物数量仍显著下降。我们强调了药物重新定位作为一种方法，它为临床批准药物找到了新的治疗意义，但适应症不同。这可以被视为一种培育策略，以提供及时且具有成本效益的解决方案，不过要克服进入市场的新药短缺问题，仍需对其进行探索。本综述聚焦于基于活性的药物重新定位方法，该方法用于探索已知药物的新用途，这些药物已被批准用于特定适应症，现在基于单一药物与多个靶点相互作用的原理被用于其他适应症。它还包括与药物重新定位相关的当前研究趋势，这依赖于对药物化学的深入了解，涉及作用机制的阐明和新靶点的验证。该综述强调了各种形式的计算工具和数据库对于药物重新定位目的的重要性，它们增强了提出合理且可测试假设的能力。在从体外或动物模型收集的数据在后续临床试验中未得到证实时，这方面的关键性质就很明显了。因此，考虑到药物重新定位的积极成果，可以推测这种方法可能是一种有前景的方法，能够发展成为一种强大的药物发现策略。
