Cardiology Department, Trakya University, Edirne, Turkey.
Cardiology Department, Derindere Hospital, Istanbul, Turkey.
Curr Cardiol Rev. 2021;17(6):e051121192311. doi: 10.2174/1573403X17666210316121842.
Fontan operation has been defined as a palliative surgery connecting systemic venous return and pulmonary circulation in patients with certain forms of complex congenital heart disease (CHD). Fortunately, it has improved overall survival and chance of successful pregnancies among these patients. However, Fontan circulation (FC), as a potential trade-off, might be associated with specific late or post-gestational complications, including peripartum cardiomyopathy (PPCM) largely through its adverse effects on the placenta and inflammation-oxidation stress. Importantly, diagnosis of superimposed PPCM in women with FC might be a diagnostic challenge, requiring a high index of suspicion. Accordingly, the present paper aims to highlight the potential association of FC with PPCM evolution largely based on certain mechanistic and clinical perspectives.
法洛四联症手术已被定义为一种姑息性手术，用于连接某些类型复杂先天性心脏病（CHD）患者的体循环静脉回流和肺循环。幸运的是，它提高了这些患者的整体生存率和成功妊娠的机会。然而，法洛四联症循环（FC）作为一种潜在的权衡，可能与特定的晚期或产后并发症有关，包括围产期心肌病（PPCM），这主要是通过其对胎盘和炎症-氧化应激的不良影响。重要的是，在 FC 女性中诊断并发 PPCM 可能是一个具有挑战性的诊断，需要高度怀疑。因此，本文旨在主要基于某些机制和临床观点强调 FC 与 PPCM 演变的潜在关联。
