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亚洲单中心经验:肾移植术后切口疝的危险因素和最佳治疗方法。

Risk Factors and Optimal Methods for Incisional Hernias After Kidney Transplantation: A Single-Center Experience From Asia.

机构信息

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Transplant Proc. 2021 Apr;53(3):1048-1054. doi: 10.1016/j.transproceed.2021.02.012. Epub 2021 Mar 13.

DOI:10.1016/j.transproceed.2021.02.012
PMID:33726941
Abstract

BACKGROUND

For kidney transplant patients, incisional hernia (IH) is a major complication resulting from prolonged pretransplant dialysis, immunosuppressive drugs, and the high prevalence of diabetes. However, there have been relatively few studies of IH after kidney transplantation (KT) in Japan and in the greater Asian population. Additionally, operative methods for IH repair have not been established.

METHODS

We retrospectively analyzed 465 consecutive patients who underwent KT at our hospital from April 2013 to March 2019. Patients who underwent incisional hernia repair were included in this study, and the follow-up time was extended to September 2020. We defined severe IH as an IH requiring surgical repair. We examine the risk factors for severe IH among KT patients and also discuss the operative methods of IH repair.

RESULTS

During the study period, 7 patients developed severe IH after KT. The cumulative occurrence rate for severe IH was 1.1% 1 year postoperatively. Multivariate logistic regression analyses showed that age at KT and dialysis duration (hazard ratio = 1.112, P = .016; hazard ratio = 1.106, respectively; P = .038) were independent risk factors for severe IH. We used polypropylene mesh for IH repair in all cases, with onlay repair performed in 5 of 7 cases. There was no recurrence or infection after mesh repair during follow-up.

CONCLUSIONS

In this study, age at KT and dialysis duration were independent risk factors for severe IH in the Japanese population. Onlay repair with a polypropylene mesh appeared to be a safe and acceptable operation for IH repair after KT.

摘要

背景

对于肾移植患者,切口疝(IH)是一种主要并发症,其原因包括移植前透析时间延长、免疫抑制剂的使用以及糖尿病的高发。然而,在日本和亚洲其他地区,关于肾移植(KT)后 IH 的研究相对较少。此外,IH 修复的手术方法尚未确定。

方法

我们回顾性分析了 2013 年 4 月至 2019 年 3 月在我院接受 KT 的 465 例连续患者。本研究纳入了接受 IH 修复的患者,并将随访时间延长至 2020 年 9 月。我们将严重 IH 定义为需要手术修复的 IH。我们研究了 KT 患者发生严重 IH 的危险因素,并讨论了 IH 修复的手术方法。

结果

在研究期间,7 例患者在 KT 后发生严重 IH。术后 1 年严重 IH 的累积发生率为 1.1%。多因素 logistic 回归分析显示,KT 时的年龄和透析时间(风险比分别为 1.112,P =.016;风险比为 1.106,P =.038)是严重 IH 的独立危险因素。我们在所有病例中均使用聚丙烯网片进行 IH 修复,其中 7 例中有 5 例采用了覆盖修复。在随访期间,网片修复后无复发或感染。

结论

在本研究中,KT 时的年龄和透析时间是日本人群中严重 IH 的独立危险因素。聚丙烯网片覆盖修复似乎是 KT 后 IH 修复的一种安全且可接受的手术方法。

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