严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）与中东呼吸综合征冠状病毒（MERS-CoV）合并感染：一个独特的病例系列。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) coinfection: A unique case series.
机构信息
Adult Critical Care Department, Dr. Sulaiman Alhabib Medical Group, Riyadh, Saudi Arabia.
Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Travel Med Infect Dis. 2021 May-Jun;41:102026. doi: 10.1016/j.tmaid.2021.102026. Epub 2021 Mar 13.
INTRODUCTION
The emergence of the Severe Acute Respiratory Syndrome Coroanvirus 2 (SARS-CoV-2) had raised possibilities of coinfection with the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in countries were these two viruses were reported. In this study, we describe the clinical presentation and demographics of eight patients who were coinfected with SARS-CoV-2 and MERS-CoV.
MATERIALS AND METHODS
This is a case series of hospitalized patients admitted to intensive care units (ICUs). We collected demographics, underlying conditions, presenting symptoms and clinical outcome from the patients' medical records.
RESULTS
During the study period from March 14, 2020 to October 19, 2020, there was a total of 67 SARS-CoV-2 ICU admitted patients who underwent simultaneous SARS-CoV-2 and MERS-CoV testing by PCR. Of those patients, 8 (12%) tested positive for both SARS-CoV-2 and MERS-CoV. There were 6 (75%) males, the mean age ± SD was 44.4 ± 11.8 years, and 7 (87.5%) were obese. Of the patients, 7 (87.5%) were non-smokers, 1 (12.5%) had diabetes mellitus, 1 (12.5%) had heart failure, and 1 (12.5%) had been on anti-platelet therapy. The mean hospital length of stay (LOS) was 21.1 ± 11.6 days and the average ICU LOS was 10.9 ± 6.03 days. All patients received supportive therapy and all were treated with corticosteroid. Of all the patients, 4 (50%) were discharged home and 3 (37.5%) died.
CONCLUSION
This case series is an important addition to the medical knowledge as it showed the interaction of the coinfection of SARS-CoV-2 and MERS-CoV.
简介
严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）的出现增加了在报告这两种病毒的国家与中东呼吸综合征冠状病毒（MERS-CoV）合并感染的可能性。在这项研究中，我们描述了 8 例同时感染 SARS-CoV-2 和 MERS-CoV 的住院患者的临床表现和人口统计学特征。
材料和方法
这是一组重症监护病房（ICU）住院患者的病例系列。我们从患者的病历中收集人口统计学、基础疾病、临床表现和临床结局的数据。
结果
在 2020 年 3 月 14 日至 2020 年 10 月 19 日的研究期间，共有 67 例 SARS-CoV-2 ICU 入院患者接受了同时进行的 SARS-CoV-2 和 MERS-CoV PCR 检测。其中 8 例（12%）同时检测出 SARS-CoV-2 和 MERS-CoV 阳性。患者中男性 6 例（75%），平均年龄 ± 标准差为 44.4 ± 11.8 岁，7 例（87.5%）肥胖。患者中 7 例（87.5%）不吸烟，1 例（12.5%）患有糖尿病，1 例（12.5%）患有心力衰竭，1 例（12.5%）正在接受抗血小板治疗。平均住院时间（LOS）为 21.1 ± 11.6 天，平均 ICU LOS 为 10.9 ± 6.03 天。所有患者均接受支持治疗，均接受皮质类固醇治疗。所有患者中，4 例（50%）出院回家，3 例（37.5%）死亡。
结论
本病例系列是对医学知识的重要补充，因为它显示了 SARS-CoV-2 和 MERS-CoV 合并感染的相互作用。
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