Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka, Eiheiji, Fukui, 910-1193, Japan.
Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.
Sci Rep. 2021 Mar 16;11(1):6018. doi: 10.1038/s41598-021-85495-w.
Intraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.
眼内手术会引起眼内炎症增加。如果这种炎症在手术后持续很长时间，可能会引起各种并发症，包括结膜下纤维化和滤泡瘢痕形成。本临床试验为前瞻性、随机、单盲、干预性研究，比较了 26 例接受超声乳化白内障吸除术和人工晶状体植入术后的白内障术后患者的房水中多种炎症细胞因子抑制作用的 0.1%溴芬酸钠滴眼液和 0.02%氟米龙滴眼液的疗效和安全性。患者随机分配至试验药物组，在给药前后采集房水样本。两组血小板衍生生长因子-AA 水平均显著降低，但氟米龙组显著高于溴芬酸钠组（P = 0.034）。溴芬酸钠还显著降低血管内皮生长因子水平（P = 0.0077），以及单核细胞趋化蛋白-1 水平（P = 0.013），这在白内障超声乳化术后持续时间延长。这些数据表明，溴芬酸钠可有效缓解白内障术后患者房水中长时间的微环境改变。
