Nemati Marzieh, Ranjbar Omrani GolamHossein, Ebrahimi Bahareh, Alizadeh Aliakbar
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Stem Cells Int. 2021 Feb 25;2021:6652915. doi: 10.1155/2021/6652915. eCollection 2021.
Over the recent years, the use of stem cells has provided a new opportunity to treat various disorders including diabetes. Stem cells are unspecialized cells with a capacity for self-renewal and differentiation into more specialized cell types. Many factors contribute to the differentiation of SCs and thus play an important role in regulating the fate of stem cells. Accordingly, a wide range of protocols has been used to differentiate SCs to insulin-producing cells but the effectiveness of SC differentiation varies. The aim of this systematic review was to evaluate the results obtained from different studies on SC differentiation for higher efficacy to treat diabetes. This search was done in PubMed, Web of Science (WOS), and Scopus using keywords "insulin-producing cell (IPC)," "pancreatic B cell," "insulin-secreting cell," "stem cell," "progenitor cells," "mother cell," and "colony-forming unit." Among more than 3646 papers, 32 studies were considered eligible for more evaluations. The obtained results indicated that most of the studies were performed on the mesenchymal stem cells (MSCs) derived from different tissues as compared with other types of SCs. Different evaluations of studies as well as animal models supported their role in the recovery of diabetes. In the present review, we summarize and discuss recent advances in increasing the efficiency of SC differentiation using different materials, but despite the promising results of this systematic review, further studies are needed to assess the efficiency and safety of transplantation of these cells in diabetes recovery.
近年来，干细胞的应用为治疗包括糖尿病在内的各种疾病提供了新的契机。干细胞是未分化的细胞，具有自我更新以及分化为更特殊细胞类型的能力。许多因素促成了干细胞的分化，因此在调节干细胞命运方面发挥着重要作用。相应地，已经采用了多种方案将干细胞分化为胰岛素生成细胞，但干细胞分化的有效性各不相同。本系统评价的目的是评估不同研究中关于干细胞分化以提高治疗糖尿病疗效所获得的结果。在PubMed、科学网（WOS）和Scopus数据库中进行检索，使用的关键词有“胰岛素生成细胞（IPC）”、“胰腺β细胞”、“胰岛素分泌细胞”、“干细胞”、“祖细胞”、“母细胞”和“集落形成单位”。在3646多篇论文中，有32项研究被认为符合进一步评估的条件。获得的结果表明，与其他类型的干细胞相比，大多数研究是在源自不同组织的间充质干细胞（MSC）上进行的。对研究以及动物模型的不同评估支持了它们在糖尿病恢复中的作用。在本综述中，我们总结并讨论了使用不同材料提高干细胞分化效率的最新进展，但是尽管本系统评价取得了有前景的结果，仍需要进一步研究来评估这些细胞移植在糖尿病恢复中的有效性和安全性。
