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腰多裂肌损伤与退变机制的研究进展

Research Progress on the Mechanism of Lumbarmultifidus Injury and Degeneration.

作者信息

Wang Xianzheng, Jia Rui, Li Jiaqi, Zhu Yibo, Liu Huanan, Wang Weijian, Sun Yapeng, Zhang Fei, Guo Lei, Zhang Wei

机构信息

Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, 050000 Hebei Province, China.

Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, China.

出版信息

Oxid Med Cell Longev. 2021 Feb 26;2021:6629037. doi: 10.1155/2021/6629037. eCollection 2021.

DOI:10.1155/2021/6629037
PMID:33728023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7936897/
Abstract

This review summarizes recent research progress in the clinical features, image manifestations, and pathological mechanism of multifidus injury. After a brief introduction to the fiber classification, innervation, blood supply, and multifidus function, some factors of multifidus injury, consisting of denervation, intraoperative incision selection and traction, and lumbar degenerative disease are overviewed. In addition, the clinical index of multifidus injury including myoglobin, creatine kinase, IL-6, C-reactive protein, the cross-sectional area of multifidus, the degree of fat infiltration, and intraoperative biopsy are summarized. Furthermore, we recommend that patients with chronic low back pain should take the long-term exercise of lumbodorsal muscles. Finally, some remaining issues, including external fixation and the imaging quantitative evaluation criteria of multifidus, need to be further explored in the future.

摘要

本文综述了多裂肌损伤的临床特征、影像表现及病理机制的最新研究进展。在简要介绍了多裂肌的纤维分类、神经支配、血液供应及功能后，概述了多裂肌损伤的一些因素，包括去神经支配、术中切口选择与牵拉以及腰椎退行性疾病。此外，总结了多裂肌损伤的临床指标，包括肌红蛋白、肌酸激酶、白细胞介素-6、C反应蛋白、多裂肌横截面积、脂肪浸润程度及术中活检。此外，我们建议慢性下腰痛患者应长期进行腰背肌锻炼。最后，一些遗留问题，包括多裂肌的外固定及影像学定量评估标准，未来还需要进一步探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/b8f7e1f89c8b/OMCL2021-6629037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/851fad04341e/OMCL2021-6629037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/fa026e2095e3/OMCL2021-6629037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/b8f7e1f89c8b/OMCL2021-6629037.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/851fad04341e/OMCL2021-6629037.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/fa026e2095e3/OMCL2021-6629037.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc6f/7936897/b8f7e1f89c8b/OMCL2021-6629037.003.jpg

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[4]
Identifying the miRNA-gene networks contributes to exploring paravertebral muscle degeneration's underlying pathogenesis and therapy strategy.

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[5]
Magnetic Resonance Imaging Evaluation of Multifidus Muscle in Patients with Low Back Pain after Microlumbar Discectomy Surgery.

J Clin Med. 2023-9-22

[6]
Characteristics of paraspinal muscle fat infiltration in asymptomatic Chinese adults: a cross-sectional study.

Quant Imaging Med Surg. 2023-7-1

[7]
Multifidus dysfunction and restorative neurostimulation: a scoping review.

Pain Med. 2023-12-1

[8]
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本文引用的文献

[1]
Fat infiltration in the multifidus muscle is related to inflammatory cytokine expression in the muscle and epidural adipose tissue in individuals undergoing surgery for intervertebral disc herniation.

Eur Spine J. 2021-4

[2]
Exercise and Low Back Pain in the Older Adult: Current Recommendations.

J Allied Health. 2019

[3]
A Novel Inextensible Endoscopic Tube Versus Traditional Extensible Retractor System in Single-Level Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Prospective Observation Study.

Pain Physician. 2019-11

[4]
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.

Int J Biol Sci. 2019-9-7

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Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.

Ageing Res Rev. 2019-10-24

[6]
Biopsy samples from the erector spinae of persons with nonspecific chronic low back pain display a decrease in glycolytic muscle fibers.

Spine J. 2019-9-27

[7]
Correlation between multifidus fatty atrophy and lumbar disc degeneration in low back pain.

BMC Musculoskelet Disord. 2019-9-5

[8]
Correlation between multifidus muscle atrophy, spinopelvic parameters, and severity of deformity in patients with adult degenerative scoliosis: the parallelogram effect of LMA on the diagonal through the apical vertebra.

J Orthop Surg Res. 2019-8-28

[9]
Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain.

Oxid Med Cell Longev. 2019-6-2

[10]
Evaluation of lumbar multifidus muscle in patients with lumbar disc herniation: are complex quantitative MRI measurements needed?

J Int Med Res. 2019-8

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