Li Ming, Guo Jiguang, Wang Hongjie, Li Yuzhen
School of Basic Medical Sciences, Hebei University, Baoding, Hebei Province, China.
Affiliated Hospital of Hebei University, Baoding, Hebei Province, China.
Oxid Med Cell Longev. 2021 Feb 26;2021:6685468. doi: 10.1155/2021/6685468. eCollection 2021.
General anesthesia is a powerful and indispensable tool to ensure the accomplishment of surgical procedures or clinical examinations. Sevoflurane as an inhalational anesthetic without unpleasant odor is commonly used in clinical practice, especially for pediatric surgery. However, the toxicity caused by sevoflurane has gained growing attention. Mitochondria play a key role in maintaining cellular metabolism and survival. To maintain the stability of mitochondrial homeostasis, they are constantly going through fusion and fission. Also, damaged mitochondria need to be degraded by autophagy, termed as mitophagy. Accumulating evidence proves that sevoflurane exposure in young age could lead to cell toxicity by triggering the mitochondrial pathway of apoptosis, inducing the abnormalities of mitochondrial dynamics and mitophagy. In the present review, we focus on the current understanding of mitochondrial apoptosis, dynamics and mitophagy in cell function, the implications for cell toxicity in response to sevoflurane, and their underlying potential mechanisms.
全身麻醉是确保外科手术或临床检查得以完成的一种强大且不可或缺的工具。七氟醚作为一种无难闻气味的吸入性麻醉剂，在临床实践中被广泛使用，尤其是在儿科手术中。然而，七氟醚引起的毒性已日益受到关注。线粒体在维持细胞代谢和存活方面起着关键作用。为了维持线粒体稳态的稳定性，它们不断经历融合和分裂。此外，受损的线粒体需要通过自噬进行降解，即线粒体自噬。越来越多的证据表明，幼年时期接触七氟醚可通过触发细胞凋亡的线粒体途径、诱导线粒体动力学和线粒体自噬异常而导致细胞毒性。在本综述中，我们重点关注目前对线粒体凋亡、动力学和线粒体自噬在细胞功能中的理解，七氟醚对细胞毒性的影响及其潜在机制。
