Charoenngam Nipith, Sriussadaporn Sutin
Vitamin D,Skin and Bone Research Laboratory, Section of Endocrinology,Nutrition,and Diabetes, Department of Medicine, Boston University Medical Center, Boston, MA, USA.
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Nutr Metab. 2021 Feb 28;2021:8899931. doi: 10.1155/2021/8899931. eCollection 2021.
Little is known about the association among skin color, sunlight exposure. and vitamin D status in Southeast Asian population.
To investigate the association between skin color measured by von Luschan chromatic scale (VLCS) and vitamin D status in Thai medical ambulatory patients.
Medical ambulatory patients were enrolled. The eligibility criteria were as follows: aged >18 years, stable medical conditions, and no conditions directly affecting vitamin D status. Serum 25-hydroxyvitamin D [25(OH)D] levels were assessed. Skin color at the outer forearm was assessed using VLCS which grades skin color from the lightest score of 1 to the darkest score of 36. Patients were systematically interviewed to estimate daily sunlight exposure time.
A total of 334 patients were enrolled. Data were expressed as mean ± SD. The mean serum 25(OH)D was 25.21 ± 10.06 ng/mL. There were 17 (5.1%), 217 (65.0%), and 100 (29.9%) patients who had light brown (VLCS score 18-20), medium brown (VLCS score 21-24), and dark brown (VLCS score 25-27) skin colors, respectively. The mean serum 25(OH)D level was higher in patients with dark brown skin than in patients with medium brown and light brown skin (28.31 ± 10.34 24.28 ± 9.57 and 19.43 ± 9.92 ng/mL, respectively, both < 0.05). Multivariate analysis showed that darker skin color and increased sunlight exposure time were independently associated with decreased odds of vitamin D deficiency (dark brown vs. light brown: odds ratio, 0.263, 95% CI: 0.081-0.851, =0.026; medium brown vs. light brown: odds ratio, 0.369, 95% CI: 0.987-1.003, =0.067; sunlight exposure time odds ratio per 1 minute/day increase 0.955, 95% CI: 0.991-1.000, =0.037), after adjusting for possible confounders.
We found that darker skin color at sunlight exposure area and increased sunlight exposure time were independently associated with decreased odds of vitamin D deficiency in Thai medical ambulatory patients.
在东南亚人群中，关于肤色、阳光暴露与维生素D状态之间的关联鲜为人知。
研究采用冯·卢尚色标（VLCS）测量的肤色与泰国门诊患者维生素D状态之间的关联。
纳入门诊患者。纳入标准如下：年龄>18岁，病情稳定，且无直接影响维生素D状态的疾病。评估血清25-羟基维生素D[25(OH)D]水平。使用VLCS评估前臂外侧的肤色，该方法将肤色从最浅的1分至最深的36分进行分级。对患者进行系统访谈以估计每日阳光暴露时间。
共纳入334例患者。数据以均数±标准差表示。血清25(OH)D的均值为25.21±10.06 ng/mL。浅棕色（VLCS评分18 - 20）、中等棕色（VLCS评分21 - 24）和深棕色（VLCS评分25 - 27）皮肤颜色的患者分别有17例（5.1%）、217例（65.0%）和100例（29.9%）。深棕色皮肤患者的血清25(OH)D平均水平高于中等棕色和浅棕色皮肤患者（分别为28.31±10.34、24.28±9.57和19.43±9.92 ng/mL，均P<0.05）。多因素分析显示，在调整可能的混杂因素后，肤色较深和阳光暴露时间增加与维生素D缺乏几率降低独立相关（深棕色与浅棕色相比：比值比，0.263，95%CI：0.081 - 0.851，P = 0.026；中等棕色与浅棕色相比：比值比，0.369，95%CI：0.987 - 1.003，P = 0.067；阳光暴露时间每增加1分钟/天，比值比0.955，95%CI：0.991 - 1.000，P = 0.037）。
我们发现，在泰国门诊患者中，阳光暴露部位肤色较深和阳光暴露时间增加与维生素D缺乏几率降低独立相关。
