Al-Daghri Nasser M, Al-Saleh Yousef, Khan Nasiruddin, Sabico Shaun, Aljohani Naji, Alfawaz Hanan, Alsulaimani Maha, Al-Othman Abdulaziz M, Alokail Majed S
Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Saudi Arabia; Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Saudi Arabia.
Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Saudi Arabia; King Abdulaziz Medical City, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11426, Saudi Arabia.
J Steroid Biochem Mol Biol. 2016 Nov;164:235-238. doi: 10.1016/j.jsbmb.2016.05.012. Epub 2016 May 12.
Accumulating evidence suggests an increased prevalence of vitamin D deficiency in the Middle East and North African countries. Sunlight has long been recognized as a major provider of vitamin D and lighter skin color has been associated with better vitamin D status. In this context, we aimed to determine whether 25-hydroxyvitamin D[25-(OH)D] concentrations are related to skin color, sun exposure and gender among healthy Saudi children and adults. A total of 808 Saudi children (age=14.6±0.04years) and 561 (age=31.4±0.3years) adults of both genders were included in this study. Levels of sun exposure and skin color were determined using a standard questionnaire. Anthropometry and plasma 25-(OH)D concentrations were analyzed. On the basis of duration of sun exposure (<20min vs. >20min), a significantly lower concentration of 25-(OH)D (40.9±1.2 vs. 35.5±1.8nmol/l; p<0.019) was demonstrated in dark-skinned boys with exposure time less than 20min than those exposed longer than 20min. We were unable to show an effect of sunlight exposure or skin color on vitamin D status of children or adults, except in dark-skinned boys who had lower 25(OH)D concentrations associated with limited sun exposure.
越来越多的证据表明，中东和北非国家维生素D缺乏症的患病率有所上升。长期以来，阳光一直被认为是维生素D的主要来源，而肤色较浅与更好的维生素D状态相关。在此背景下，我们旨在确定健康的沙特儿童和成年人中25-羟基维生素D[25-(OH)D]浓度是否与肤色、阳光暴露和性别有关。本研究共纳入808名沙特儿童（年龄=14.6±0.04岁）和561名（年龄=31.4±0.3岁）不同性别的成年人。使用标准问卷确定阳光暴露水平和肤色。分析人体测量数据和血浆25-(OH)D浓度。根据阳光暴露时间（<20分钟与>20分钟），暴露时间少于20分钟的深色皮肤男孩的25-(OH)D浓度（40.9±1.2与35.5±1.8nmol/l；p<0.019）明显低于暴露时间超过20分钟的男孩。我们未能证明阳光暴露或肤色对儿童或成年人的维生素D状态有影响，除了深色皮肤男孩，他们的25(OH)D浓度较低与阳光暴露有限有关。
